Promoting Mechanism of Serum Amyloid a Family Expression in Mouse Intestinal Epithelial Cells

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2022 Mar 18

PMID 35303008

Authors

Masaki Wakai

Ryohei Hayashi

Yoshitaka Ueno

Kana Onishi

Takeshi Takasago

Takuro Uchida

Hidehiko Takigawa

Ryo Yuge

Yuji Urabe

Shiro Oka

Yasuhiko Kitadai

Shinji Tanaka

Affiliations

Soon will be listed here.

Abstract

Serum amyloid A (SAA) is an acute phase inflammatory protein that we previously described as a robust biomarker of colorectal inflammation in patients with ulcerative colitis (UC) in clinical remission. However, what induces SAA expression in UC remains unclear. This study demonstrates that SAA is significantly expressed in the intestinal tract of UC mouse models when compared with C-reactive protein, another inflammatory biomarker. Moreover, interleukin-6 and tumor necrosis factor-α were found to promote SAA1 expression, as were Toll-like receptor ligands flagellin and lipopolysaccharide. Furthermore, results suggested that the nuclear factor-kappa B (NF-κB) pathway may be involved in the promotion of SAA1 expression by flagellin, which was inhibited by treatment with 5-aminosalicylic acid (5-ASA). Therefore, the flagellin/NF-κB/SAA1 axis may represent one of the mechanisms by which 5-ASA suppresses intestinal inflammation.

Citing Articles

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Serum amyloid protein A in inflammatory bowel disease: from bench to bedside.

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