Intratumoral Electroporation of Plasmid Encoded IL12 and Membrane-Anchored Anti-CD3 Increases Systemic Tumor Immunity

Overview

Journal Mol Cancer Res

Specialty Cell Biology

Date 2022 Mar 18

PMID 35302641

Authors

Mia Han

Bianca Nguyen

Jack Y Lee

Erica Browning

Jun Zhang

Anandaroop Mukhopadhyay

Ravindra Gujar

Jon Salazar

Reneta Hermiz

Lauren Svenson

Annah S Rolig

William L Redmond

Alain P Algazi

Adil I Daud

David A Canton

Christopher G Twitty

Affiliations

Soon will be listed here.

Abstract

Implications: This DNA-encodable polyclonal T-cell stimulator (membrane-anchored anti-CD3 plasmid) may represent a key addition to intratumoral IL12 therapies in the clinic.

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