Cytotoxic T Lymphocytes Against Disease-associated Determinant(s) in Ankylosing Spondylitis

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1986 Sep 1

PMID 3528379

Citations 16

Authors

A F Geczy

L E McGuigan

J S Sullivan

J P Edmonds

Affiliations

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Abstract

Cytotoxic T lymphocytes, induced by stimulating the PBMC of an HLA-B27+ normal individual (B27+, AS-) with the PBMC of an HLA-identical sibling suffering from ankylosing spondylitis (AS) (B27+, AS+), specifically lyse B27+, AS+ PBMC but not PBMC from HLA-27+ or B27-, AS- normal controls, or from HLA-B27- AS patients (B27-,AS+). CTL of similar specificity can also be raised by immunizing in vitro B27+,AS- cells with autologous cells modified by cross-reactive bacterial antigens. These results suggest that CTL can recognize certain bacterial antigens in association with HLA-B27 and that this interaction may lead to an inflammatory episode during the initial stages of the disease.

Citing Articles

Reactive arthritis: the convoluted history of Reiter's disease.

Buchanan W, Kean W, Rainsford K, Kean C Inflammopharmacology. 2023; 32(1):93-99.

PMID: 37805646 DOI: 10.1007/s10787-023-01336-4.

HLA-B27 associated spondyloarthropathy, an autoimmune disease based on crossreactivity between bacteria and HLA-B27?.

Ringrose J Ann Rheum Dis. 1999; 58(10):598-610.

PMID: 10491358 PMC: 1752789. DOI: 10.1136/ard.58.10.598.

Yersinia enterocolitica serotype O:3 alters the expression of serologic HLA-B27 epitopes on human monocytes.

Wuorela M, Jalkanen S, Kirveskari J, Laitio P, Granfors K Infect Immun. 1997; 65(6):2060-6.

PMID: 9169732 PMC: 175284. DOI: 10.1128/iai.65.6.2060-2066.1997.

Failure of the serological determination of HLA-B27 due to antigen masking in patients with ankylosing spondylitis.

Neumuller J, Fischer M, Eberl R Rheumatol Int. 1993; 13(4):163-7.

PMID: 8310210 DOI: 10.1007/BF00301265.

Possible role of HLA-B27 associated cytotoxic T lymphocyte activity in the pathogenesis of the seronegative arthropathies.

Geczy A, Sullivan J Ann Rheum Dis. 1995; 54(5):329-30.

PMID: 7540826 PMC: 1005586. DOI: 10.1136/ard.54.5.329.

References

Geczy A, Alexander K, Bashir H, Edmonds J . A factor(s) in Klebsiella culture filtrates specifically modifies an HLA-B27 associated cell-surface component. Nature. 1980; 283(5749):782-4. DOI: 10.1038/283782a0. View

Avakian H, Welsh J, Ebringer A, ENTWISTLE C . Ankylosing spondylitis, HLA-B27 and Klebsiella. II. Cross-reactivity studies with human tissue typing sera. Br J Exp Pathol. 1980; 61(1):92-6. PMC: 2041554. View

Sullivan J, Upfold L, Geczy A, Bashir H, Edmonds J . Immunochemical characterization of Klebsiella antigens which specifically modify an HLA-B27-associated cell-surface component. Hum Immunol. 1982; 5(4):295-307. DOI: 10.1016/0198-8859(82)90021-0. View

Prendergast J, Sullivan J, Geczy A, Upfold L, Edmonds J, Bashir H . Possible role of enteric organisms in the pathogenesis of ankylosing spondylitis and other seronegative arthropathies. Infect Immun. 1983; 41(3):935-41. PMC: 264591. DOI: 10.1128/iai.41.3.935-941.1983. View

McGuigan L, Geczy A, Prendergast J, Edmonds J, Hart H, Bashir H . HLA-B27 associated cross-reactive marker on the cells of New Zealand patients with ankylosing spondylitis. Ann Rheum Dis. 1986; 45(2):144-8. PMC: 1001837. DOI: 10.1136/ard.45.2.144. View