Water Extract of Selectively Exerts Estrogenic Activities in Ovariectomized Rats and Estrogen Receptor-Positive Cells

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2022 Mar 14

PMID 35282447

Authors

Liping Zhou

Ka-Ying Wong

Christina Chui-Wa Poon

Wenxuan Yu

Huihui Xiao

Chi-On Chan

Daniel Kam-Wah Mok

Man-Sau Wong

Affiliations

Soon will be listed here.

Abstract

Our previous study demonstrated that the bone protective actions of herbal medicine (Gusuibu, RD) were mainly mediated by flavonoid phytoestrogens estrogen receptors, raising concerns about the safety of using RD as it may induce estrogen-like risk-benefit profile and interact with other ER ligands, such as selective estrogen receptor modulators (SERMs), when coadministered. The present study evaluated the estrogenic activities of RD and its potential interaction with tamoxifen, a SERM, in estrogen-sensitive tissues by using mature ovariectomized (OVX) rats and ER-positive cells. Similar to but weaker than tamoxifen, RD at its clinical dose dramatically ameliorated OVX-induced changes in bone and dopamine metabolism-related markers in OVX rats. However, tamoxifen, but not RD, induced uterotrophic effects. No significant alteration in mammary gland was observed in OVX rats treated with RD, which was different from the inhibitory actions of tamoxifen. The two-way ANOVA results indicated the interactions between RD and tamoxifen in the bone, brain, and uterus of OVX rats while RD did not alter their responses to tamoxifen. Our results demonstrate that RD selectively exerts estrogenic actions in a different manner from tamoxifen. Moreover, RD interacts with tamoxifen without altering its effects in OVX rats.

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