Low Hemoglobin is Associated with Worse Outcomes Via Larger Hematoma Volume in Intracerebral Hemorrhage Due to Systemic Disease

Overview

Journal MedComm (2020)

Specialty Health Services

Date 2022 Mar 14

PMID 35281786

Authors

Shuting Zhang

Yang Shu

Yunlong Chen

Xiaoyang Liu

Yu Liu

Yajun Cheng

Bo Wu

Peng Lei

Ming Liu

Affiliations

Soon will be listed here.

Abstract

Whether hemoglobin is associated with outcomes of a specific subtype of intracerebral hemorrhage (ICH) is unknown. A total of 4643 patients with ICH from a multicenter cohort were included in the analysis (64.0% male; mean age [SD], 58.3 [15.2] year), of whom 1319 (28.4%) had anemia on admission. The unsupervised consensus cluster method was employed to classify the patients into three clusters. The patients of cluster 3 were characterized by a high frequency of anemia (85.3%) and mainly composed of patients of systemic disease ICH subtype (SD-ICH; 90.0%) according to the SMASH-U etiologies. In SD-ICH, a strong interaction effect was observed between anemia and 3-month death (adjusted odds ratio [aOR] 4.33, 95% confidence interval [CI] 1.60-11.9, = 0.004), and the hemoglobin levels were linearly associated with 3-month death (aOR 0.75, 95% CI 0.60-0.92; = 0.009), which was partially mediated by larger baseline hematoma volume (= 0.008). This study demonstrated a strong linear association between low hemoglobin levels and worse outcomes in SD-ICH, suggesting that hemoglobin-elevating therapy might be extensively needed in a specific subtype of ICH.

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