Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2022 Mar 14

PMID 35281057

Authors

Shaoping She

Liying Ren

Pu Chen

Mingyang Wang

Dongbo Chen

Ying Wang

Hongsong Chen

Affiliations

Soon will be listed here.

Abstract

Chemokines are a family of cytokines that orchestrate the migration and positioning of immune cells within tissues and are critical for the function of the immune system. CCR2 participates in liver pathology, including acute liver injury, chronic hepatitis, fibrosis/cirrhosis, and tumor progression, by mediating the recruitment of immune cells to inflammation and tumor sites. Although a variety of chemokines have been well studied in various diseases, there is no comprehensive review presenting the roles of all known chemokine ligands of CCR2 (CCL2, CCL7, CCL8, CCL12, CCL13, CCL16, and PSMP) in liver disease, and this review aims to fill this gap. The introduction of each chemokine includes its discovery, its corresponding chemotactic receptors, physiological functions and roles in inflammation and tumors, and its impact on different immune cell subgroups.

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