Radiotherapy for the Treatment of Pulmonary Hydatidosis in Sheep

Overview

Journal Open Life Sci

Specialty Biology

Date 2022 Mar 11

PMID 35274045

Authors

Yuefen Zhang

Pengfei Lu

Hongzhi Qi

Ge Wu

Rui Mao

Yongxing Bao

Affiliations

Soon will be listed here.

Abstract

Hydatidosis is an endemic disease causing a severe threat to public health. Drugs and surgery have been utilized for treatment, but their efficiency is not adequate. Therefore, new methods are required for treating such diseases. In this study, we attempt to evaluate the efficiency of radiotherapy for hydatidosis in sheep. The sheep naturally infected with pulmonary hydatid were randomly divided into four groups, including the control group subjected to no irradiation and the other three groups subjected to 30, 45, and 60 Gy irradiation, respectively. Gene expression of and and protein expression of BCL-2 and BAX in the lung tissues were evaluated after treatment. Our data showed that the irradiation with a dose of 30, 45, and 60 Gy significantly induced the expression of and . Immunohistochemical staining showed that the BCL-2 protein was downregulated after exposure to 45 Gy of irradiation, whereas the BAX expression was downregulated after irradiation at a dose of 45 and 60 Gy, respectively. On this basis, we speculated that 45 Gy might be a safe and effective dose for treating pulmonary hydatidosis in sheep, which induced lower expression of and in the cyst and a downregulation of BCL-2 and BAX in the adjacent lung tissues.

Citing Articles

Safety of Three-Dimensional Conformal Radiotherapy on the Sheep with Pulmonary Cystic Echinococcosis: A Preliminary Study.

Zhang Y, Lu P, Qi H, Mao R, Bao Y Acta Parasitol. 2024; 69(1):559-566.

PMID: 38233676 DOI: 10.1007/s11686-023-00751-5.

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