Rapid Inactivation of Dabie Bandavirus (SFTSV) by Irradiation with Deep-ultraviolet Light-emitting Diode

Overview

Journal J Med Virol

Specialty Microbiology

Date 2022 Mar 5

PMID 35246855

Authors

Chiho Kaneko

Akatsuki Saito

Hiroko Inagaki

Hironobu Sugiyama

Eugene Mazimpaka

Shouichi Fujimoto

Tamaki Okabayashi

Affiliations

Soon will be listed here.

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) caused by Dabie bandavirus (SFTSV) is a serious public health concern in endemic areas, particularly in Asian and Southeast Asian countries. SFTSV is transmitted by direct contact with body fluids from infected humans and animals. Therefore, environmental hygiene in hospitals and veterinary clinics in SFTSV-endemic areas is highly important. This study assessed the effects of continuous and intermittent irradiation with deep-ultraviolet light-emitting diode (DUV-LED) on SFTSV. Evaluation was performed by conducting plaque assay in which SFTSV irradiated with deep-ultraviolet (DUV; 280 ± 5 nm) was inoculated onto Vero cells. The results showed that continuous and intermittent irradiation for 5 s, resulting in 18.75 mJ/cm of cumulative UV exposure, led to a >2.7 and >2.9 log reduction, respectively, corresponding to a >99.8% reduction in infectivity. These results demonstrate that DUV can be utilized for inactivation of SFTSV to maintain environmental hygiene in hospitals and veterinary clinics in endemic countries.

Citing Articles

Usefulness of a new DUV-LED device for the control of infection by , mycobacteria and spore-forming bacteria.

Inagaki H, Goto Y, Sugiyama H, Saito A, Okabayashi T, Watanabe K Front Public Health. 2022; 10:1053729.

PMID: 36544797 PMC: 9760979. DOI: 10.3389/fpubh.2022.1053729.

Rapid inactivation of Dabie bandavirus (SFTSV) by irradiation with deep-ultraviolet light-emitting diode.

Kaneko C, Saito A, Inagaki H, Sugiyama H, Mazimpaka E, Fujimoto S J Med Virol. 2022; 94(7):3438-3441.

PMID: 35246855 PMC: 9314962. DOI: 10.1002/jmv.27698.

References

Takahashi T, Maeda K, Suzuki T, Ishido A, Shigeoka T, Tominaga T . The first identification and retrospective study of Severe Fever with Thrombocytopenia Syndrome in Japan. J Infect Dis. 2013; 209(6):816-27. PMC: 7107388. DOI: 10.1093/infdis/jit603. View

Kim K, Yi J, Kim G, Choi S, Jun K, Kim N . Severe fever with thrombocytopenia syndrome, South Korea, 2012. Emerg Infect Dis. 2013; 19(11):1892-4. PMC: 3837670. DOI: 10.3201/eid1911.130792. View

Yu X, Liang M, Zhang S, Liu Y, Li J, Sun Y . Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med. 2011; 364(16):1523-32. PMC: 3113718. DOI: 10.1056/NEJMoa1010095. View

Gai Z, Liang M, Zhang Y, Zhang S, Jin C, Wang S . Person-to-person transmission of severe fever with thrombocytopenia syndrome bunyavirus through blood contact. Clin Infect Dis. 2011; 54(2):249-52. PMC: 3245727. DOI: 10.1093/cid/cir776. View

Kuhn J, Adkins S, Alioto D, Alkhovsky S, Amarasinghe G, Anthony S . 2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales. Arch Virol. 2020; 165(12):3023-3072. PMC: 7606449. DOI: 10.1007/s00705-020-04731-2. View

Niu G, Li J, Liang M, Jiang X, Jiang M, Yin H . Severe fever with thrombocytopenia syndrome virus among domesticated animals, China. Emerg Infect Dis. 2013; 19(5):756-63. PMC: 3647489. DOI: 10.3201/eid1905.120245. View

Tran X, Yun Y, Van An L, Kim S, Thao N, Man P . Endemic Severe Fever with Thrombocytopenia Syndrome, Vietnam. Emerg Infect Dis. 2019; 25(5):1029-1031. PMC: 6478219. DOI: 10.3201/eid2505.181463. View

Yamanaka A, Kirino Y, Fujimoto S, Ueda N, Himeji D, Miura M . Direct Transmission of Severe Fever with Thrombocytopenia Syndrome Virus from Domestic Cat to Veterinary Personnel. Emerg Infect Dis. 2020; 26(12):2994-2998. PMC: 7706950. DOI: 10.3201/eid2612.191513. View

Lin T, Ou S, Maeda K, Shimoda H, Chan J, Tu W . The first discovery of severe fever with thrombocytopenia syndrome virus in Taiwan. Emerg Microbes Infect. 2020; 9(1):148-151. PMC: 6968498. DOI: 10.1080/22221751.2019.1710436. View

10.

Beck S, Rodriguez R, Linden K, Hargy T, Larason T, Wright H . Wavelength dependent UV inactivation and DNA damage of adenovirus as measured by cell culture infectivity and long range quantitative PCR. Environ Sci Technol. 2013; 48(1):591-8. DOI: 10.1021/es403850b. View

11.

Inagaki H, Saito A, Kaneko C, Sugiyama H, Okabayashi T, Fujimoto S . Rapid Inactivation of SARS-CoV-2 Variants by Continuous and Intermittent Irradiation with a Deep-Ultraviolet Light-Emitting Diode (DUV-LED) Device. Pathogens. 2021; 10(6). PMC: 8232135. DOI: 10.3390/pathogens10060754. View

12.

Kaneko C, Saito A, Inagaki H, Sugiyama H, Mazimpaka E, Fujimoto S . Rapid inactivation of Dabie bandavirus (SFTSV) by irradiation with deep-ultraviolet light-emitting diode. J Med Virol. 2022; 94(7):3438-3441. PMC: 9314962. DOI: 10.1002/jmv.27698. View

13.

Lo C, Matsuura R, Iimura K, Wada S, Shinjo A, Benno Y . UVC disinfects SARS-CoV-2 by induction of viral genome damage without apparent effects on viral morphology and proteins. Sci Rep. 2021; 11(1):13804. PMC: 8257663. DOI: 10.1038/s41598-021-93231-7. View

14.

Kirino Y, Ishijima K, Miura M, Nomachi T, Mazimpaka E, Sudaryatma P . Seroprevalence of Severe Fever with Thrombocytopenia Syndrome Virus in Small-Animal Veterinarians and Nurses in the Japanese Prefecture with the Highest Case Load. Viruses. 2021; 13(2). PMC: 7912989. DOI: 10.3390/v13020229. View

15.

Hayasaka D, Fuxun Y, Yoshikawa A, Posadas-Herrera G, Shimada S, Ngwe Tun M . Seroepidemiological evidence of severe fever with thrombocytopenia syndrome virus infections in wild boars in Nagasaki, Japan. Trop Med Health. 2016; 44:6. PMC: 4940765. DOI: 10.1186/s41182-016-0009-6. View

16.

Sato Y, Mekata H, Sudaryatma P, Kirino Y, Yamamoto S, Ando S . Isolation of Severe Fever with Thrombocytopenia Syndrome Virus from Various Tick Species in Area with Human Severe Fever with Thrombocytopenia Syndrome Cases. Vector Borne Zoonotic Dis. 2021; 21(5):378-384. DOI: 10.1089/vbz.2020.2720. View

17.

Beck S, Rodriguez R, Hawkins M, Hargy T, Larason T, Linden K . Comparison of UV-Induced Inactivation and RNA Damage in MS2 Phage across the Germicidal UV Spectrum. Appl Environ Microbiol. 2015; 82(5):1468-1474. PMC: 4771313. DOI: 10.1128/AEM.02773-15. View

18.

Ma B, Gundy P, Gerba C, Sobsey M, Linden K . UV Inactivation of SARS-CoV-2 across the UVC Spectrum: KrCl* Excimer, Mercury-Vapor, and Light-Emitting-Diode (LED) Sources. Appl Environ Microbiol. 2021; 87(22):e0153221. PMC: 8552892. DOI: 10.1128/AEM.01532-21. View