Hyperpolarized Carbon 13 MRI in Liver Diseases: Recent Advances and Future Opportunities

Overview

Journal Liver Int

Specialty Gastroenterology

Date 2022 Mar 1

PMID 35230742

Authors

Zheng Ye

Bin Song

Philip M Lee

Michael A Ohliger

Christoffer Laustsen

Affiliations

Soon will be listed here.

Abstract

Hyperpolarized carbon-13 magnetic resonance imaging (HP C MRI) is a recently translated metabolic imaging technique. With dissolution dynamic nuclear polarization (d-DNP), more than 10 000-fold signal enhancement can be readily reached, making it possible to visualize real-time metabolism and specific substrate-to-metabolite conversions in the liver after injecting carbon-13 labelled probes. Increasing evidence suggests that HP C MRI is a potential tool in detecting liver abnormalities, predicting disease progression and monitoring response treatment. In this review, we will introduce the recent progresses of HP C MRI in diffuse liver diseases and liver malignancies and discuss its future opportunities from a clinical perspective, hoping to provide a comprehensive overview of this novel technique in liver diseases and highlight its scientific and clinical potential in the field of hepatology.

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