NOTCH3 As a Modulator of Vascular Disease: a Target in Elastin Deficiency and Arterial Pathologies

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2022 Mar 1

PMID 35229725

Authors

Kimberly Malka

Lucy Liaw

Affiliations

Soon will be listed here.

Abstract

During blood vessel disease, vascular smooth muscle cell (VSMC) expansion and interaction with the matrix trigger changes in gene expression and phenotype. In this issue of the JCI, Dave et al. discover a signaling network that drives VSMC expansion and vascular obstruction caused by elastin insufficiency. Using a combination of gene-targeted mice, tissues and cells from patients with Williams-Beuren syndrome, and targeting of elastin in human VSMCs, the authors identified VSMC-derived NOTCH3 signaling as a critical mediator of aortic hypermuscularization and loss of vascular patency. NOTCH3-specific therapies or therapies that target downstream molecular pathways may provide opportunities to minimize VSMC growth and treat cardiovascular disease with minimal side effects.

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