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Nontuberculous Mycobacterium-associated Immune Reconstitution Inflammatory Syndrome in a Non-HIV Immunosuppressed Patient

Overview
Journal Respirol Case Rep
Date 2022 Mar 1
PMID 35228890
Authors
Misato Kobayashi
Yukari Tsubata
Yohei Shiratsuki
Takamasa Hotta
Megumi Hamaguchi
Takeshi Isobe
Affiliations
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Abstract

A 69-year-old woman with rheumatoid arthritis, using immunosuppressants, including etanercept-a tumour necrosis factor (TNF)-α antagonist-was referred to our hospital with fever and fatigue. Chest computed tomography revealed cavities in the left upper lobe. As infection was diagnosed, all immunosuppressants were discontinued, and treatment with anti-nontuberculous Mycobacterium drugs was initiated. However, her condition worsened paradoxically. We diagnosed immune reconstitution inflammatory syndrome (IRIS) resulting from the discontinuation of the TNF-α antagonist. Her condition improved with prednisolone treatment. IRIS is generally observed during HIV treatment, but a good understanding of immunosuppressant-related non-HIV IRIS is needed.

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Nontuberculous Mycobacterium-associated immune reconstitution inflammatory syndrome in a non-HIV immunosuppressed patient.

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References
1.
Kobayashi M, Tsubata Y, Shiratsuki Y, Hotta T, Hamaguchi M, Isobe T . Nontuberculous Mycobacterium-associated immune reconstitution inflammatory syndrome in a non-HIV immunosuppressed patient. Respirol Case Rep. 2022; 10(3):e0918. PMC: 8864326. DOI: 10.1002/rcr2.918. View
2.
Gupta M, Jafri K, Sharim R, Silverman S, Sindher S, Shahane A . Immune reconstitution inflammatory syndrome associated with biologic therapy. Curr Allergy Asthma Rep. 2014; 15(2):499. DOI: 10.1007/s11882-014-0499-4. View
3.
Takazono T, Nakamura S, Imamura Y, Miyazaki T, Izumikawa K, Kakeya H . Paradoxical response to disseminated non-tuberculosis mycobacteriosis treatment in a patient receiving tumor necrosis factor-α inhibitor: a case report. BMC Infect Dis. 2014; 14:114. PMC: 3942211. DOI: 10.1186/1471-2334-14-114. View
4.
Sueki H, Mizukawa Y, Aoyama Y . Immune reconstitution inflammatory syndrome in non-HIV immunosuppressed patients. J Dermatol. 2017; 45(1):3-9. DOI: 10.1111/1346-8138.14074. View
5.
Sun H, Singh N . Immune reconstitution inflammatory syndrome in non-HIV immunocompromised patients. Curr Opin Infect Dis. 2009; 22(4):394-402. DOI: 10.1097/QCO.0b013e32832d7aff. View