Dual-Specificity Phosphatases and Kidney Diseases

Overview

Journal Kidney Dis (Basel)

Specialty Nephrology

Date 2022 Feb 28

PMID 35224004

Authors

Haiyang Li

Jiachuan Xiong

Yu Du

Yinghui Huang

Jinghong Zhao

Affiliations

Soon will be listed here.

Abstract

Background: Dual-specificity phosphatases (DUSPs) belong to the family of protein tyrosine phosphatases, which can dephosphorylate both serine/threonine and tyrosine residues. During the past decades, DUSPs have been implicated in various physiological and pathological activities. Besides mitogen-activated protein kinases (MAPKs) as the main substrates, other protein and nonprotein substrates can also be dephosphorylated by DUSPs. Aberrant regulations of DUSPs have been found in various diseases such as cancer, neurological disorders, and kidney diseases, suggesting the involvement of DUSPs in the pathogenesis of diseases.

Summary: In this review, we summarize the general characteristics of DUSPs and the research progress made in the field of kidney diseases, including diabetic nephropathy, hypertensive nephropathy, chronic kidney disease, acute kidney injury, and lupus nephritis. As the main biochemical function of DUSPs is to dephosphorylate MAPKs activity, decreased DUSPs are found in kidney disease models, whereas forced DUSPs expression reverses the disease presentation, which was proved by using transgenic or gene knockout model.

Key Messages: Mounting evidence demonstrates that DUSPs have essential physiological and pathological functions in kidney disease. Fully understanding the functions and mechanisms of DUSPs in kidney disease contributes to their clinical application in translation medicine.

Citing Articles

Genome-wide characterization and comparative expression profiling of genes in yellow catfish () after infection with exogenous .

Guo S, Zeng M, Zhang C, Fan Y, Ran M, Song Z Front Immunol. 2024; 15:1481696.

PMID: 39606227 PMC: 11598348. DOI: 10.3389/fimmu.2024.1481696.

Development and evaluation of a chronic kidney disease risk prediction model using random forest.

Mendapara K Front Genet. 2024; 15:1409755.

PMID: 38993480 PMC: 11236722. DOI: 10.3389/fgene.2024.1409755.

Revealing the Complete Bispecific Phosphatase Genes (DUSPs) across the Genome and Investigating the Expression Patterns of GH_A11G3500 Resistance against .

Deng Y, Deng X, Zhao J, Ning S, Gu A, Chen Q Int J Mol Sci. 2024; 25(8).

PMID: 38674085 PMC: 11050305. DOI: 10.3390/ijms25084500.

Molecular Docking Analysis of Selected Urtica dioica Constituents As Human Carbonic Anhydrase II (hCA-II), Human 11 Beta-Hydroxysteroid Dehydrogenases Type 1 (h11beta-HSD1), and Human Dual Specificity Phosphatase (hCDC25B) Inhibitory Agents.

Arulselvan A, Manimuthu M, Narayanaswamy R Cureus. 2024; 16(2):e53886.

PMID: 38465091 PMC: 10925072. DOI: 10.7759/cureus.53886.

Minichromosome maintenance 6 protects against renal fibrogenesis by regulating DUSP6-mediated ERK/GSK-3β/Snail1 signaling.

Huang J, Xu Z, Liu F, Song A, Su H, Zhang C iScience. 2023; 26(10):107940.

PMID: 37810227 PMC: 10558752. DOI: 10.1016/j.isci.2023.107940.

References

Kondoh K, Nishida E . Regulation of MAP kinases by MAP kinase phosphatases. Biochim Biophys Acta. 2007; 1773(8):1227-37. DOI: 10.1016/j.bbamcr.2006.12.002. View

Kidger A, Keyse S . The regulation of oncogenic Ras/ERK signalling by dual-specificity mitogen activated protein kinase phosphatases (MKPs). Semin Cell Dev Biol. 2016; 50:125-32. PMC: 5056954. DOI: 10.1016/j.semcdb.2016.01.009. View

Sakai N, Wada T, Furuichi K, Iwata Y, Yoshimoto K, Kitagawa K . Involvement of extracellular signal-regulated kinase and p38 in human diabetic nephropathy. Am J Kidney Dis. 2005; 45(1):54-65. DOI: 10.1053/j.ajkd.2004.08.039. View

Salazar C, Hofer T . Multisite protein phosphorylation--from molecular mechanisms to kinetic models. FEBS J. 2009; 276(12):3177-98. DOI: 10.1111/j.1742-4658.2009.07027.x. View

Jeong Y, Du R, Zhu X, Yin S, Wang J, Cui H . Histone deacetylase isoforms regulate innate immune responses by deacetylating mitogen-activated protein kinase phosphatase-1. J Leukoc Biol. 2013; 95(4):651-9. DOI: 10.1189/jlb.1013565. View

Kincaid R, Lam V, Chirayil R, Randall G, Sullivan C . RNA triphosphatase DUSP11 enables exonuclease XRN-mediated restriction of hepatitis C virus. Proc Natl Acad Sci U S A. 2018; 115(32):8197-8202. PMC: 6094126. DOI: 10.1073/pnas.1802326115. View

Mutlak M, Kehat I . Dual specific phosphatases (DUSPs) in cardiac hypertrophy and failure. Cell Signal. 2021; 84:110033. DOI: 10.1016/j.cellsig.2021.110033. View

Sousa-Lopes A, de Freitas R, Silva Carneiro F, Nunes K, Allahdadi K, Webb R . Angiotensin (1-7) Inhibits Ang II-mediated ERK1/2 Activation by Stimulating MKP-1 Activation in Vascular Smooth Muscle Cells. Int J Mol Cell Med. 2020; 9(1):50-61. PMC: 7422848. DOI: 10.22088/IJMCM.BUMS.9.1.50. View

Kurtzeborn K, Kwon H, Kuure S . MAPK/ERK Signaling in Regulation of Renal Differentiation. Int J Mol Sci. 2019; 20(7). PMC: 6479953. DOI: 10.3390/ijms20071779. View

10.

Patterson K, Brummer T, OBrien P, Daly R . Dual-specificity phosphatases: critical regulators with diverse cellular targets. Biochem J. 2009; 418(3):475-89. DOI: 10.1042/bj20082234. View

11.

Wu J, Mei C, Vlassara H, Striker G, Zheng F . Oxidative stress-induced JNK activation contributes to proinflammatory phenotype of aging diabetic mesangial cells. Am J Physiol Renal Physiol. 2009; 297(6):F1622-31. PMC: 2801342. DOI: 10.1152/ajprenal.00078.2009. View

12.

Charles C, Abler A, Lau L . cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein. Oncogene. 1992; 7(1):187-90. View

13.

Thongnuanjan P, Soodvilai S, Chatsudthipong V, Soodvilai S . Fenofibrate reduces cisplatin-induced apoptosis of renal proximal tubular cells via inhibition of JNK and p38 pathways. J Toxicol Sci. 2016; 41(3):339-49. DOI: 10.2131/jts.41.339. View

14.

Coit P, Renauer P, Jeffries M, Merrill J, McCune W, Maksimowicz-McKinnon K . Renal involvement in lupus is characterized by unique DNA methylation changes in naïve CD4+ T cells. J Autoimmun. 2015; 61:29-35. PMC: 4497927. DOI: 10.1016/j.jaut.2015.05.003. View

15.

Rodrigues-Diez R, Carvajal-Gonzalez G, Sanchez-Lopez E, Rodriguez-Vita J, Rodrigues Diez R, Selgas R . Pharmacological modulation of epithelial mesenchymal transition caused by angiotensin II. Role of ROCK and MAPK pathways. Pharm Res. 2008; 25(10):2447-61. DOI: 10.1007/s11095-008-9636-x. View

16.

Kidger A, Rushworth L, Stellzig J, Davidson J, Bryant C, Bayley C . Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling. Proc Natl Acad Sci U S A. 2017; 114(3):E317-E326. PMC: 5255582. DOI: 10.1073/pnas.1614684114. View

17.

Kucharska A, Rushworth L, Staples C, Morrice N, Keyse S . Regulation of the inducible nuclear dual-specificity phosphatase DUSP5 by ERK MAPK. Cell Signal. 2009; 21(12):1794-805. DOI: 10.1016/j.cellsig.2009.07.015. View

18.

Denhez B, Rousseau M, Dancosst D, Lizotte F, Guay A, Auger-Messier M . Diabetes-Induced DUSP4 Reduction Promotes Podocyte Dysfunction and Progression of Diabetic Nephropathy. Diabetes. 2019; 68(5):1026-1039. DOI: 10.2337/db18-0837. View

19.

Wang S, Zhang Z, Wang J, Miao H . MiR-107 induces TNF-α secretion in endothelial cells causing tubular cell injury in patients with septic acute kidney injury. Biochem Biophys Res Commun. 2017; 483(1):45-51. DOI: 10.1016/j.bbrc.2017.01.013. View

20.

An N, Bassil K, Al Jowf G, Steinbusch H, Rothermel M, de Nijs L . Dual-specificity phosphatases in mental and neurological disorders. Prog Neurobiol. 2020; 198:101906. DOI: 10.1016/j.pneurobio.2020.101906. View