SPINKs in Tumors: Potential Therapeutic Targets

Overview

Journal Front Oncol

Specialty Oncology

Date 2022 Feb 28

PMID 35223512

Authors

Chengcheng Liao

Qian Wang

Jiaxing An

Minglin Zhang

Jie Chen

Xiaolan Li

Linlin Xiao

Jiajia Wang

Qian Long

Jianguo Liu

Xiaoyan Guan

Affiliations

Soon will be listed here.

Abstract

The serine protease inhibitor Kazal type (SPINK) family includes SPINK1-14 and is the largest branch in the serine protease inhibitor family. SPINKs play an important role in pancreatic physiology and disease, sperm maturation and capacitation, Nager syndrome, inflammation and the skin barrier. Evidence shows that the unregulated expression of SPINK1, 2, 4, 5, 6, 7, and 13 is closely related to human tumors. Different SPINKs exhibit various regulatory modes in different tumors and can be used as tumor prognostic markers. This article reviews the role of SPINK1, 2, 4, 5, 6, 7, and 13 in different human cancer processes and helps to identify new cancer treatment targets.

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