Integrin-Mediated Tumorigenesis and Its Therapeutic Applications

Overview

Journal Front Oncol

Specialty Oncology

Date 2022 Feb 28

PMID 35223494

Authors

Qingling Li

Ting Lan

Jian Xie

Youguang Lu

Dali Zheng

Bohua Su

Affiliations

Soon will be listed here.

Abstract

Integrins, a family of adhesion molecules generally exist on the cell surface, are essential for regulating cell growth and its function. As a bi-directional signaling molecule, they mediate cell-cell and cell-extracellular matrix interaction. The recognitions of their key roles in many human pathologies, including autoimmunity, thrombosis and neoplasia, have revealed their great potential as a therapeutic target. This paper focuses on the activation of integrins, the role of integrins in tumorigenesis and progression, and advances of integrin-dependent tumor therapeutics in recent years. It is expected that understanding function and signaling transmission will fully exploit potentialities of integrin as a novel target for tumors.

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