The Effects of Ginsenosides on PI3K/AKT Signaling Pathway

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2022 Feb 27

PMID 35220526

Authors

Soudeh Ghafouri-Fard

Neda Balaei

Hamed Shoorei

Syed Muhammad Farid Hasan

Bashdar Mahmud Hussen

Seyedeh Fahimeh Talebi

Mohammad Taheri

Seyed Abdulmajid Ayatollahi

Affiliations

Soon will be listed here.

Abstract

Ginsenosides belong to a group of steroid glycosides that are extracted from the plant genus Panax (ginseng). This plant has been used for a long time for the treatment of a variety of disorders in traditional medicine. Recent studies have assessed the biological impact of Ginsenosides in cell culture or animal models. Animal studies have shown their beneficial impacts in the remedy of pathological conditions in different tissues. The ameliorating effects of Ginsenosides in diverse pathogenic conditions can be attributed to their effects on the production of reactive oxygen species. These substances mainly affect the activity of AMPK/AKT and PI3K/AKT pathways. The beneficial effects of Ginsenosides have been appraised in diabetes-related complications, spinal cord injury, cerebral ischemia, myocardial ischemia, and other disorders which are associated with oxidative stress. Moreover, these substances have been shown to interfere with the pathologic conditions during carcinogenesis. In the current study, we explain these impacts in two distinct sections including non-neoplastic conditions and neoplastic conditions.

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