Novel Porcine Circoviruses in View of Lessons Learned from Porcine Circovirus Type 2-Epidemiology and Threat to Pigs and Other Species

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2022 Feb 26

PMID 35215854

Authors

Hanna Turlewicz-Podbielska

Agata Augustyniak

Malgorzata Pomorska-Mol

Affiliations

Soon will be listed here.

Abstract

Porcine circovirus type 2 (PCV2) plays a key role in PCV2-associated disease (PCVAD) etiology and has yielded significant losses in the pig husbandry in the last 20 years. However, the impact of two recently described species of porcine circoviruses, PCV3 and PCV4, on the pork industry remains unknown. The presence of PCV3 has been associated with several clinical presentations in pigs. Reproductive failure and multisystemic inflammation have been reported most consistently. The clinical symptoms, anatomopathological changes and interaction with other pathogens during PCV3 infection in pigs indicate that PCV3 might be pathogenic for these animals and can cause economic losses in the swine industry similar to PCV2, which makes PCV3 worth including in the differential list as a cause of clinical disorders in reproductive swine herds. Moreover, subsequent studies indicate interspecies transmission and worldwide spreading of PCV3. To date, research related to PCV3 and PCV4 vaccine design is at early stage, and numerous aspects regarding immune response and virus characteristics remain unknown.

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References

Tischer I, Rasch R, Tochtermann G . Characterization of papovavirus-and picornavirus-like particles in permanent pig kidney cell lines. Zentralbl Bakteriol Orig A. 1974; 226(2):153-67. View

Sun W, Du Q, Han Z, Bi J, Lan T, Wang W . Detection and genetic characterization of porcine circovirus 4 (PCV4) in Guangxi, China. Gene. 2020; 773:145384. DOI: 10.1016/j.gene.2020.145384. View

Jiang Z, Wu J, Jiang M, Xie Y, Bu W, Liu C . A Novel Technique for Constructing Infectious Cloning of Type 3 Porcine Circovirus. Front Microbiol. 2020; 11:1067. PMC: 7296095. DOI: 10.3389/fmicb.2020.01067. View

Ilha M, Nara P, Ramamoorthy S . Early antibody responses map to non-protective, PCV2 capsid protein epitopes. Virology. 2019; 540:23-29. DOI: 10.1016/j.virol.2019.11.008. View

Molini U, Marruchella G, Matheus F, Hemberger Y, Chiwome B, Khaiseb S . Molecular Investigation of Porcine Circovirus Type 3 Infection in Pigs in Namibia. Pathogens. 2021; 10(5). PMC: 8150967. DOI: 10.3390/pathogens10050585. View

Feng H, Blanco G, Segales J, Sibila M . Can Porcine circovirus type 2 (PCV2) infection be eradicated by mass vaccination?. Vet Microbiol. 2014; 172(1-2):92-9. DOI: 10.1016/j.vetmic.2014.05.003. View

Zou Y, Zhang N, Zhang J, Zhang S, Jiang Y, Wang D . Molecular detection and sequence analysis of porcine circovirus type 3 in sow sera from farms with prolonged histories of reproductive problems in Hunan, China. Arch Virol. 2018; 163(10):2841-2847. DOI: 10.1007/s00705-018-3914-7. View

Wang T, Chai W, Wang Y, Liu W, Huang Z, Chen L . First detection and phylogenetic analysis of porcine circovirus 3 in female donkeys with reproductive disorders. BMC Vet Res. 2021; 17(1):308. PMC: 8449920. DOI: 10.1186/s12917-021-03013-6. View

Mankertz A, Persson F, Mankertz J, Blaess G, Buhk H . Mapping and characterization of the origin of DNA replication of porcine circovirus. J Virol. 1997; 71(3):2562-6. PMC: 191374. DOI: 10.1128/JVI.71.3.2562-2566.1997. View

10.

Cao L, Sun W, Lu H, Tian M, Xie C, Zhao G . Genetic variation analysis of PCV1 strains isolated from Guangxi Province of China in 2015. BMC Vet Res. 2018; 14(1):43. PMC: 5803923. DOI: 10.1186/s12917-018-1345-z. View

11.

Wang D, Mai J, Lei B, Zhang Y, Yang Y, Wang N . Structure, Antigenic Properties, and Highly Efficient Assembly of PCV4 Capsid Protein. Front Vet Sci. 2021; 8:695466. PMC: 8421537. DOI: 10.3389/fvets.2021.695466. View

12.

Ellis J, Hassard L, Clark E, Harding J, Allan G, Willson P . Isolation of circovirus from lesions of pigs with postweaning multisystemic wasting syndrome. Can Vet J. 1998; 39(1):44-51. PMC: 1539838. View

13.

Song S, Park K, Choe S, Cha R, Shin J, Hyun B . Complete Genome Sequences of Two Type 3 Porcine Circoviruses, WB17KW and WB20GG, Isolated from Korean Wild Boar. Microbiol Resour Announc. 2021; 10(6). PMC: 7883834. DOI: 10.1128/MRA.01386-20. View

14.

Alomar J, Saporiti V, Perez M, Goncalvez D, Sibila M, Segales J . Multisystemic lymphoplasmacytic inflammation associated with PCV-3 in wasting pigs. Transbound Emerg Dis. 2021; 68(6):2969-2974. DOI: 10.1111/tbed.14260. View

15.

Stadejek T, Wozniak A, Milek D, Biernacka K . First detection of porcine circovirus type 3 on commercial pig farms in Poland. Transbound Emerg Dis. 2017; 64(5):1350-1353. DOI: 10.1111/tbed.12672. View

16.

Wang F, Guo X, Ge X, Wang Z, Chen Y, Cha Z . Genetic variation analysis of Chinese strains of porcine circovirus type 2. Virus Res. 2009; 145(1):151-6. DOI: 10.1016/j.virusres.2009.05.015. View

17.

Weibel H, Sydler T, Brugnera E, Voets H, Grosse Liesner B, Sidler X . Efficacy of simultaneous vaccination with Enterisol® Ileitis and Ingelvac® CircoFLEXTM in a Swiss breeding farm. Schweiz Arch Tierheilkd. 2012; 154(10):445-50. DOI: 10.1024/0036-7281/a000381. View

18.

Ku X, Chen F, Li P, Wang Y, Yu X, Fan S . Identification and genetic characterization of porcine circovirus type 3 in China. Transbound Emerg Dis. 2017; 64(3):703-708. PMC: 7169768. DOI: 10.1111/tbed.12638. View

19.

Zhang H, Hu W, Li J, Liu T, Zhou J, Opriessnig T . Novel circovirus species identified in farmed pigs designated as Porcine circovirus 4, Hunan province, China. Transbound Emerg Dis. 2019; 67(3):1057-1061. DOI: 10.1111/tbed.13446. View

20.

Nguyen V, Do H, Huynh T, Park Y, Park B, Chung H . Molecular-based detection, genetic characterization and phylogenetic analysis of porcine circovirus 4 from Korean domestic swine farms. Transbound Emerg Dis. 2021; 69(2):538-548. DOI: 10.1111/tbed.14017. View