Lower Impact of Disease on Daily Life and Less Fatigue in Patients With Inflammatory Bowel Disease Following a Lifestyle Intervention

Overview

Journal Inflamm Bowel Dis

Publisher Oxford University Press

Specialty Gastroenterology

Date 2022 Feb 25

PMID 35212382

Authors

Carlijn R Lamers

Nicole M de Roos

Henrike H Heerink

Linda A van de Worp-Kalter

Ben J M Witteman

Affiliations

Soon will be listed here.

Abstract

Background: Despite the potential benefits of diet and physical activity, evidence for beneficial effects of a combined lifestyle intervention is lacking in patients with inflammatory bowel disease (IBD). Therefore, we assessed its effects on impact of disease on daily life, clinical disease activity, fatigue, and health-related quality of life (HRQoL) in patients with IBD.

Methods: A 6-month single-arm intervention study was performed in adult IBD patients in remission or with mildly active disease. Participants received personal dietary and physical activity advice from a dietician and a physiotherapist in 6 consults. At baseline and over time, questionnaires on diet quality, physical activity, and disease-related outcomes were completed and fecal calprotectin was determined. Data were analyzed by linear mixed models.

Results: During the intervention, diet quality significantly increased (P < .001), but the level of physical activity remained the same. Over time, impact of the disease on daily life reduced (P = .009) and fatigue decreased (P = .001), while clinical disease activity, HRQoL, and fecal calprotectin did not change. Improvement in diet quality was significantly associated with a lower impact of disease on daily life (β = 0.09; 95% confidence interval [CI], 0.03 to 0.15; P = .003) and less fatigue (β = -0.13; 95% CI, -0.20 to -0.07; P < .001) but not with clinical disease activity, HRQoL, and fecal calprotectin. No associations were found with physical activity.

Conclusions: This combined lifestyle intervention significantly improved diet quality, and this improvement was associated with a reduction in the impact of disease on daily life and fatigue in patients with IBD in remission or with mildly active disease.

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References

Bilski J, Mazur-Bialy A, Brzozowski B, Magierowski M, Zahradnik-Bilska J, Wojcik D . Can exercise affect the course of inflammatory bowel disease? Experimental and clinical evidence. Pharmacol Rep. 2016; 68(4):827-36. DOI: 10.1016/j.pharep.2016.04.009. View

Bolte L, Vich Vila A, Imhann F, Collij V, Gacesa R, Peters V . Long-term dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut microbiome. Gut. 2021; 70(7):1287-1298. PMC: 8223641. DOI: 10.1136/gutjnl-2020-322670. View

Ishak W, Pan D, Steiner A, Feldman E, Mann A, Mirocha J . Patient-Reported Outcomes of Quality of Life, Functioning, and GI/Psychiatric Symptom Severity in Patients with Inflammatory Bowel Disease (IBD). Inflamm Bowel Dis. 2017; 23(5):798-803. DOI: 10.1097/MIB.0000000000001060. View

Klare P, Nigg J, Nold J, Haller B, Krug A, Mair S . The impact of a ten-week physical exercise program on health-related quality of life in patients with inflammatory bowel disease: a prospective randomized controlled trial. Digestion. 2015; 91(3):239-47. DOI: 10.1159/000371795. View

Weggemans R, Backx F, Borghouts L, Chinapaw M, Hopman M, Koster A . The 2017 Dutch Physical Activity Guidelines. Int J Behav Nutr Phys Act. 2018; 15(1):58. PMC: 6016137. DOI: 10.1186/s12966-018-0661-9. View

Michie S, Richardson M, Johnston M, Abraham C, Francis J, Hardeman W . The behavior change technique taxonomy (v1) of 93 hierarchically clustered techniques: building an international consensus for the reporting of behavior change interventions. Ann Behav Med. 2013; 46(1):81-95. DOI: 10.1007/s12160-013-9486-6. View

Chicco F, Magri S, Cingolani A, Paduano D, Pesenti M, Zara F . Multidimensional Impact of Mediterranean Diet on IBD Patients. Inflamm Bowel Dis. 2020; 27(1):1-9. PMC: 7737160. DOI: 10.1093/ibd/izaa097. View

Lo C, Khalili H, Song M, Lochhead P, Burke K, Richter J . Healthy Lifestyle Is Associated With Reduced Mortality in Patients With Inflammatory Bowel Diseases. Clin Gastroenterol Hepatol. 2020; 19(1):87-95.e4. PMC: 7483199. DOI: 10.1016/j.cgh.2020.02.047. View

Lewis J, Abreu M . Diet as a Trigger or Therapy for Inflammatory Bowel Diseases. Gastroenterology. 2016; 152(2):398-414.e6. DOI: 10.1053/j.gastro.2016.10.019. View

10.

Torres J, Ellul P, Langhorst J, Mikocka-Walus A, Barreiro-de Acosta M, Basnayake C . European Crohn's and Colitis Organisation Topical Review on Complementary Medicine and Psychotherapy in Inflammatory Bowel Disease. J Crohns Colitis. 2019; 13(6):673-685e. DOI: 10.1093/ecco-jcc/jjz051. View

11.

Wong C, Harris P, Ferguson L . Potential Benefits of Dietary Fibre Intervention in Inflammatory Bowel Disease. Int J Mol Sci. 2016; 17(6). PMC: 4926452. DOI: 10.3390/ijms17060919. View

12.

Lo B, Prosberg M, Gluud L, Chan W, Leong R, van der List E . Systematic review and meta-analysis: assessment of factors affecting disability in inflammatory bowel disease and the reliability of the inflammatory bowel disease disability index. Aliment Pharmacol Ther. 2017; 47(1):6-15. DOI: 10.1111/apt.14373. View

13.

Engels M, Cross R, Long M . Exercise in patients with inflammatory bowel diseases: current perspectives. Clin Exp Gastroenterol. 2018; 11:1-11. PMC: 5743119. DOI: 10.2147/CEG.S120816. View

14.

Monda V, Villano I, Messina A, Valenzano A, Esposito T, Moscatelli F . Exercise Modifies the Gut Microbiota with Positive Health Effects. Oxid Med Cell Longev. 2017; 2017:3831972. PMC: 5357536. DOI: 10.1155/2017/3831972. View

15.

Ammar A, Brach M, Trabelsi K, Chtourou H, Boukhris O, Masmoudi L . Effects of COVID-19 Home Confinement on Eating Behaviour and Physical Activity: Results of the ECLB-COVID19 International Online Survey. Nutrients. 2020; 12(6). PMC: 7352706. DOI: 10.3390/nu12061583. View

16.

Elsenbruch S, Langhorst J, Popkirowa K, Muller T, Luedtke R, Franken U . Effects of mind-body therapy on quality of life and neuroendocrine and cellular immune functions in patients with ulcerative colitis. Psychother Psychosom. 2005; 74(5):277-87. DOI: 10.1159/000086318. View

17.

Jones P, Kappelman M, Martin C, Chen W, Sandler R, Long M . Exercise decreases risk of future active disease in patients with inflammatory bowel disease in remission. Inflamm Bowel Dis. 2015; 21(5):1063-71. PMC: 4402239. DOI: 10.1097/MIB.0000000000000333. View

18.

Bennebroek Evertsz F, Hoeks C, Nieuwkerk P, Stokkers P, Ponsioen C, Bockting C . Development of the patient Harvey Bradshaw index and a comparison with a clinician-based Harvey Bradshaw index assessment of Crohn's disease activity. J Clin Gastroenterol. 2013; 47(10):850-6. DOI: 10.1097/MCG.0b013e31828b2196. View

19.

Campmans-Kuijpers M, Dijkstra G . Food and Food Groups in Inflammatory Bowel Disease (IBD): The Design of the Groningen Anti-Inflammatory Diet (GrAID). Nutrients. 2021; 13(4). PMC: 8064481. DOI: 10.3390/nu13041067. View

20.

Czuber-Dochan W, Norton C, Bassett P, Berliner S, Bredin F, Darvell M . Development and psychometric testing of inflammatory bowel disease fatigue (IBD-F) patient self-assessment scale. J Crohns Colitis. 2014; 8(11):1398-406. DOI: 10.1016/j.crohns.2014.04.013. View