A Review of Optical Imaging Technologies for Microfluidics

Overview

Journal Micromachines (Basel)

Publisher MDPI

Date 2022 Feb 25

PMID 35208397

Authors

Pan Zhou

Haipeng He

Hanbin Ma

Shurong Wang

Siyi Hu

Affiliations

Soon will be listed here.

Abstract

Microfluidics can precisely control and manipulate micro-scale fluids, and are also known as lab-on-a-chip or micro total analysis systems. Microfluidics have huge application potential in biology, chemistry, and medicine, among other fields. Coupled with a suitable detection system, the detection and analysis of small-volume and low-concentration samples can be completed. This paper reviews an optical imaging system combined with microfluidics, including bright-field microscopy, chemiluminescence imaging, spectrum-based microscopy imaging, and fluorescence-based microscopy imaging. At the end of the article, we summarize the advantages and disadvantages of each imaging technology.

Citing Articles

Quantification of Lanthanides on a PMMA Microfluidic Device with Three Optical Pathlengths Using PCR of UV-Visible, NIR, and Raman Spectroscopy.

Lackey H, Espley A, Potter S, Lamadie F, Miguirditchian M, Nelson G ACS Omega. 2024; 9(37):38548-38556.

PMID: 39310177 PMC: 11411548. DOI: 10.1021/acsomega.4c03857.

On-Chip Photonic Detection Techniques for Non-Invasive In Situ Characterizations at the Microfluidic Scale.

Kurdadze T, Lamadie F, Nehme K, Teychene S, Biscans B, Rodriguez-Ruiz I Sensors (Basel). 2024; 24(5).

PMID: 38475065 PMC: 10933925. DOI: 10.3390/s24051529.

Particle Counting Methods Based on Microfluidic Devices.

Dang Z, Jiang Y, Su X, Wang Z, Wang Y, Sun Z Micromachines (Basel). 2023; 14(9).

PMID: 37763885 PMC: 10534595. DOI: 10.3390/mi14091722.

SPIM-Flow: An Integrated Light Sheet and Microfluidics Platform for Hydrodynamic Studies of .

Hedde P, Le B, Gomez E, Duong L, Steele R, Ahrar S Biology (Basel). 2023; 12(1).

PMID: 36671808 PMC: 9856110. DOI: 10.3390/biology12010116.

Editorial for the Topic on Micromachining for Advanced Biological Imaging.

Yoo Y, Song Y Micromachines (Basel). 2022; 13(3).

PMID: 35334764 PMC: 8953275. DOI: 10.3390/mi13030474.

References

Al Mughairy B, Al-Lawati H, Suliman F . Investigating the impact of metal ions and 3D printed droplet microfluidics chip geometry on the luminol‑potassium periodate chemiluminescence system for estimating total phenolic content in olive oil. Spectrochim Acta A Mol Biomol Spectrosc. 2019; 221:117182. DOI: 10.1016/j.saa.2019.117182. View

Ota N, Yonamine Y, Asai T, Yalikun Y, Ito T, Ozeki Y . Isolating Single Cells by Glass Microfluidics for Raman Analysis of Paramylon Biogenesis. Anal Chem. 2019; 91(15):9631-9639. DOI: 10.1021/acs.analchem.9b01007. View

Richmond D, Schmid E, Martens S, Stachowiak J, Liska N, Fletcher D . Forming giant vesicles with controlled membrane composition, asymmetry, and contents. Proc Natl Acad Sci U S A. 2011; 108(23):9431-6. PMC: 3111313. DOI: 10.1073/pnas.1016410108. View

Gao D, Liu H, Jiang Y, Lin J . Recent advances in microfluidics combined with mass spectrometry: technologies and applications. Lab Chip. 2013; 13(17):3309-22. DOI: 10.1039/c3lc50449b. View

Ewing A, Kazarian S . Recent advances in the applications of vibrational spectroscopic imaging and mapping to pharmaceutical formulations. Spectrochim Acta A Mol Biomol Spectrosc. 2018; 197:10-29. DOI: 10.1016/j.saa.2017.12.055. View

Teh S, Lin R, Hung L, Lee A . Droplet microfluidics. Lab Chip. 2008; 8(2):198-220. DOI: 10.1039/b715524g. View

Kubsch B, Robinson T, Lipowsky R, Dimova R . Solution Asymmetry and Salt Expand Fluid-Fluid Coexistence Regions of Charged Membranes. Biophys J. 2016; 110(12):2581-2584. PMC: 4919722. DOI: 10.1016/j.bpj.2016.05.028. View

Luo Y, Sun W, Liu C, Wang G, Fang N . Superlocalization of single molecules and nanoparticles in high-fidelity optical imaging microfluidic devices. Anal Chem. 2011; 83(13):5073-7. DOI: 10.1021/ac201056z. View

Ko J, Wang Y, Carlson J, Marquard A, Gungabeesoon J, Charest A . Single Extracellular Vesicle Protein Analysis Using Immuno-Droplet Digital Polymerase Chain Reaction Amplification. Adv Biosyst. 2020; 4(12):e1900307. PMC: 8491538. DOI: 10.1002/adbi.201900307. View

10.

Gao L, Teng Y . Exploiting plug-and-play electrochemistry for drug discovery. Future Med Chem. 2016; 8(5):567-77. DOI: 10.4155/fmc.16.8. View

11.

Regmi R, Mohan K, Mondal P . MRT letter: light sheet based imaging flow cytometry on a microfluidic platform. Microsc Res Tech. 2013; 76(11):1101-7. DOI: 10.1002/jemt.22296. View

12.

Jonkman J, Brown C, Wright G, Anderson K, North A . Tutorial: guidance for quantitative confocal microscopy. Nat Protoc. 2020; 15(5):1585-1611. DOI: 10.1038/s41596-020-0313-9. View

13.

Palocci C, Valletta A, Chronopoulou L, Donati L, Bramosanti M, Brasili E . Endocytic pathways involved in PLGA nanoparticle uptake by grapevine cells and role of cell wall and membrane in size selection. Plant Cell Rep. 2017; 36(12):1917-1928. DOI: 10.1007/s00299-017-2206-0. View

14.

Mompean M, Sanchez-Donoso R, Hoz A, Saggiomo V, Velders A, Gomez M . Pushing nuclear magnetic resonance sensitivity limits with microfluidics and photo-chemically induced dynamic nuclear polarization. Nat Commun. 2018; 9(1):108. PMC: 5760532. DOI: 10.1038/s41467-017-02575-0. View

15.

Lee S, Yang S . A microfluidic-based lid device for conventional cell culture dishes to automatically control oxygen level. Biotechniques. 2018; 64(5):231-234. DOI: 10.2144/btn-2018-0013. View

16.

Nitahara S, Maeki M, Yamaguchi H, Yamashita K, Miyazaki M, Maeda H . Three-dimensional Raman spectroscopic imaging of protein crystals deposited on a nanodroplet. Analyst. 2012; 137(24):5730-5. DOI: 10.1039/c2an35942a. View

17.

Lei K, Chang C, Chen M . Paper/PMMA Hybrid 3D Cell Culture Microfluidic Platform for the Study of Cellular Crosstalk. ACS Appl Mater Interfaces. 2017; 9(15):13092-13101. DOI: 10.1021/acsami.7b03021. View

18.

Wiktor J, Gynna A, Leroy P, Larsson J, Coceano G, Testa I . RecA finds homologous DNA by reduced dimensionality search. Nature. 2021; 597(7876):426-429. PMC: 8443446. DOI: 10.1038/s41586-021-03877-6. View

19.

Swyer I, Soong R, Dryden M, Fey M, Maas W, Simpson A . Interfacing digital microfluidics with high-field nuclear magnetic resonance spectroscopy. Lab Chip. 2016; 16(22):4424-4435. DOI: 10.1039/c6lc01073c. View

20.

Hale W, Rossetto G, Greenhalgh R, Finch G, Utz M . High-resolution nuclear magnetic resonance spectroscopy in microfluidic droplets. Lab Chip. 2018; 18(19):3018-3024. DOI: 10.1039/c8lc00712h. View