(De)Activation (Ir)Reversibly or Degradation: Dynamics of Post-Translational Protein Modifications in Plants

Overview

Journal Life (Basel)

Specialty Biology

Date 2022 Feb 25

PMID 35207610

Authors

Victor Muleya

L Maria Lois

Hicham Chahtane

Ludivine Thomas

Marco Chiapello

Claudius Marondedze

Affiliations

Soon will be listed here.

Abstract

The increasing dynamic functions of post-translational modifications (PTMs) within protein molecules present outstanding challenges for plant biology even at this present day. Protein PTMs are among the first and fastest plant responses to changes in the environment, indicating that the mechanisms and dynamics of PTMs are an essential area of plant biology. Besides being key players in signaling, PTMs play vital roles in gene expression, gene, and protein localization, protein stability and interactions, as well as enzyme kinetics. In this review, we take a broader but concise approach to capture the current state of events in the field of plant PTMs. We discuss protein modifications including citrullination, glycosylation, phosphorylation, oxidation and disulfide bridges, N-terminal, SUMOylation, and ubiquitination. Further, we outline the complexity of studying PTMs in relation to compartmentalization and function. We conclude by challenging the proteomics community to engage in holistic approaches towards identification and characterizing multiple PTMs on the same protein, their interaction, and mechanism of regulation to bring a deeper understanding of protein function and regulation in plants.

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References

Orosa-Puente B, Leftley N, von Wangenheim D, Banda J, Srivastava A, Hill K . Root branching toward water involves posttranslational modification of transcription factor ARF7. Science. 2018; 362(6421):1407-1410. DOI: 10.1126/science.aau3956. View

Kwon S, Kwon S, Bae M, Cho E, Park O . Role of the methionine sulfoxide reductase MsrB3 in cold acclimation in Arabidopsis. Plant Cell Physiol. 2007; 48(12):1713-23. DOI: 10.1093/pcp/pcm143. View

Stuhrwohldt N, Dahlke R, Kutschmar A, Peng X, Sun M, Sauter M . Phytosulfokine peptide signaling controls pollen tube growth and funicular pollen tube guidance in Arabidopsis thaliana. Physiol Plant. 2014; 153(4):643-53. DOI: 10.1111/ppl.12270. View

Yuzhalin A . Citrullination in Cancer. Cancer Res. 2019; 79(7):1274-1284. DOI: 10.1158/0008-5472.CAN-18-2797. View

Michelet L, Zaffagnini M, Morisse S, Sparla F, Perez-Perez M, Francia F . Redox regulation of the Calvin-Benson cycle: something old, something new. Front Plant Sci. 2013; 4:470. PMC: 3838966. DOI: 10.3389/fpls.2013.00470. View

Ding Y, Sun T, Ao K, Peng Y, Zhang Y, Li X . Opposite Roles of Salicylic Acid Receptors NPR1 and NPR3/NPR4 in Transcriptional Regulation of Plant Immunity. Cell. 2018; 173(6):1454-1467.e15. DOI: 10.1016/j.cell.2018.03.044. View

Aksnes H, Drazic A, Marie M, Arnesen T . First Things First: Vital Protein Marks by N-Terminal Acetyltransferases. Trends Biochem Sci. 2016; 41(9):746-760. DOI: 10.1016/j.tibs.2016.07.005. View

Zhang M, Henquet M, Chen Z, Zhang H, Zhang Y, Ren X . LEW3, encoding a putative alpha-1,2-mannosyltransferase (ALG11) in N-linked glycoprotein, plays vital roles in cell-wall biosynthesis and the abiotic stress response in Arabidopsis thaliana. Plant J. 2009; 60(6):983-99. DOI: 10.1111/j.1365-313X.2009.04013.x. View

Elrouby N . Regulation of Plant Cellular and Organismal Development by SUMO. Adv Exp Med Biol. 2017; 963:227-247. DOI: 10.1007/978-3-319-50044-7_14. View

10.

Wang X, Goshe M, Soderblom E, Phinney B, Kuchar J, Li J . Identification and functional analysis of in vivo phosphorylation sites of the Arabidopsis BRASSINOSTEROID-INSENSITIVE1 receptor kinase. Plant Cell. 2005; 17(6):1685-703. PMC: 1143070. DOI: 10.1105/tpc.105.031393. View

11.

Klareskog L, Lundberg K, Malmstrom V . Autoimmunity in rheumatoid arthritis: citrulline immunity and beyond. Adv Immunol. 2013; 118:129-58. DOI: 10.1016/B978-0-12-407708-9.00003-0. View

12.

Muleya V, Marondedze C, Wheeler J, Thomas L, Mok Y, Griffin M . Phosphorylation of the dimeric cytoplasmic domain of the phytosulfokine receptor, PSKR1. Biochem J. 2016; 473(19):3081-98. DOI: 10.1042/BCJ20160593. View

13.

Matsuzaki Y, Ogawa-Ohnishi M, Mori A, Matsubayashi Y . Secreted peptide signals required for maintenance of root stem cell niche in Arabidopsis. Science. 2010; 329(5995):1065-7. DOI: 10.1126/science.1191132. View

14.

Cao H, Li X, Wang Z, Ding M, Sun Y, Dong F . Histone H2B Monoubiquitination Mediated by HISTONE MONOUBIQUITINATION1 and HISTONE MONOUBIQUITINATION2 Is Involved in Anther Development by Regulating Tapetum Degradation-Related Genes in Rice. Plant Physiol. 2015; 168(4):1389-405. PMC: 4528728. DOI: 10.1104/pp.114.256578. View

15.

Castro P, Bachmair A, R Bejarano E, Coupland G, Lois L, Sadanandom A . Revised nomenclature and functional overview of the ULP gene family of plant deSUMOylating proteases. J Exp Bot. 2018; 69(19):4505-4509. PMC: 6117577. DOI: 10.1093/jxb/ery301. View

16.

Kim J, Park H, Chae S, Lee T, Hwang D, Oh S . A pepper MSRB2 gene confers drought tolerance in rice through the protection of chloroplast-targeted genes. PLoS One. 2014; 9(3):e90588. PMC: 3948683. DOI: 10.1371/journal.pone.0090588. View

17.

ROGERS G, Simmonds D . Content of citrulline and other amino-acids in a protein of hair follicles. Nature. 1958; 182(4629):186-7. DOI: 10.1038/182186a0. View

18.

Gibbs D, Bacardit J, Bachmair A, Holdsworth M . The eukaryotic N-end rule pathway: conserved mechanisms and diverse functions. Trends Cell Biol. 2014; 24(10):603-11. DOI: 10.1016/j.tcb.2014.05.001. View

19.

Linster E, Stephan I, Bienvenut W, Maple-Grodem J, Myklebust L, Huber M . Downregulation of N-terminal acetylation triggers ABA-mediated drought responses in Arabidopsis. Nat Commun. 2015; 6:7640. PMC: 4530475. DOI: 10.1038/ncomms8640. View

20.

Zhang B, Holmlund M, Lorrain S, Norberg M, Bako L, Fankhauser C . BLADE-ON-PETIOLE proteins act in an E3 ubiquitin ligase complex to regulate PHYTOCHROME INTERACTING FACTOR 4 abundance. Elife. 2017; 6. PMC: 5582868. DOI: 10.7554/eLife.26759. View