Lac Repressor Blocks Transcribing RNA Polymerase and Terminates Transcription

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1986 Jun 1

PMID 3520567

Citations 50

Authors

U Deuschle

R Gentz

H Bujard

Affiliations

Soon will be listed here.

Abstract

Operator sequences are essential elements in many negatively controlled operons. By binding repressors, they prevent the formation of active complexes between RNA polymerase and promoters. Here we show that the Escherichia coli lac operator-repressor complex also efficiently interrupts ongoing transcription. This observation suggests a mechanism of action for operators located distal to promoter sequences.

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