Chitosan-Based Films with 2-Aminothiophene Derivative: Formulation, Characterization and Potential Antifungal Activity

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2022 Feb 24

PMID 35200633

Authors

Veronica da Silva Oliveira

Meriangela Miranda da Cruz

Gabriela Suassuna Bezerra

Natan Emanuell Sobral E Silva

Fernando Henrique Andrade Nogueira

Guilherme Maranhao Chaves

Jose Lamartine Soares Sobrinho

Francisco Jaime Bezerra Mendonca-Junior

Bolivar Ponciano Goulart de Lima Damasceno

Attilio Converti

Adley Antonini Neves de Lima

Affiliations

Soon will be listed here.

Abstract

In this study, films of chitosan and 2-amino-4,5,6,7-tetrahydrobenzo[]thiophene-3-carbonitrile (6CN), a 2-aminothiophene derivative with great pharmacological potential, were prepared as a system for a topical formulation. 6CN-chitosan films were characterized by physicochemical analyses, such as Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-ray diffraction (XRD), and scanning electronic microscopy (SEM). Additionally, the antifungal potential of the films was evaluated in vitro against three species of (, , and ). The results of the FTIR and thermal analysis showed the incorporation of 6CN in the polymer matrix. In the diffractogram, the 6CN-chitosan films exhibited diffraction halos that were characteristic of amorphous structures, while the micrographs showed that 6CN particles were dispersed in the chitosan matrix, exhibiting pores and cracks on the film surface. In addition, the results of antifungal investigation demonstrated that 6CN-chitosan films were effective against species showing potential for application as a new antifungal drug.

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