Stereoselective Biocatalyzed Reductions of Ginger Active Components Recovered from Industrial Wastes

Overview

Journal Chembiochem

Specialty Biochemistry

Date 2022 Feb 21

PMID 35188325

Authors

Rita Nasti

Ivan Bassanini

Erica Elisa Ferrandi

Federica Linguardo

Susanna Bertuletti

Marta Vanoni

Sergio Riva

Luisella Verotta

Daniela Monti

Affiliations

Soon will be listed here.

Abstract

Ginger is among the most widespread and widely consumed traditional medicinal plants around the world. Its beneficial effects, which comprise e. g. anticancer and anti-inflammatory activities as well as gastrointestinal regulatory effects, are generally attributed to a family of non-volatile compounds characterized by an arylalkyl long-chained alcohol, diol, or ketone moiety. In this work, ginger active components have been successfully recovered from industrial waste biomass of fermented ginger. Moreover, their recovery has been combined with the first systematic study of the stereoselective reduction of gingerol-like compounds by isolated alcohol dehydrogenases (ADHs), obtaining the enantioenriched sec-alcohol derivatives via a sustainable biocatalytic path in up to >99 % conversions and >99 % enantiomeric/diastereomeric excesses.

Citing Articles

Functional Characterization and Synthetic Application of Is2-SDR, a Novel Thermostable and Promiscuous Ketoreductase from a Hot Spring Metagenome.

Ferrandi E, Bassanini I, Bertuletti S, Riva S, Tognoli C, Vanoni M Int J Mol Sci. 2022; 23(20).

PMID: 36293010 PMC: 9603792. DOI: 10.3390/ijms232012153.

Stereoselective Biocatalyzed Reductions of Ginger Active Components Recovered from Industrial Wastes.

Nasti R, Bassanini I, Ferrandi E, Linguardo F, Bertuletti S, Vanoni M Chembiochem. 2022; 23(8):e202200105.

PMID: 35188325 PMC: 9314113. DOI: 10.1002/cbic.202200105.

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