Cortical and White Matter Lesion Topology Influences Focal Corpus Callosum Atrophy in Multiple Sclerosis

Overview

Journal J Neuroimaging

Publisher Wiley

Specialties Neurology
Radiology

Date 2022 Feb 15

PMID 35165979

Authors

Michael Platten

Russell Ouellette

Elena Herranz

Valeria Barletta

Constantina A Treaba

Caterina Mainero

Tobias Granberg

Affiliations

Soon will be listed here.

Abstract

Background And Purpose: Corpus callosum (CC) atrophy is a strong predictor of multiple sclerosis (MS) disability but the contributing pathological mechanisms remain uncertain. We aimed to apply advanced MRI to explore what drives the often nonuniform callosal atrophy.

Methods: Prospective brain 7 Tesla and 3 Tesla Human Connectom Scanner MRI were performed in 92 MS patients. White matter, leukocortical, and intracortical lesions were manually segmented. FreeSurfer was used to segment the CC and topographically classify lesions per lobe or as deep white matter lesions. Regression models were calculated to predict focal CC atrophy.

Results: The frontal and parietal lobes contained the majority (≥80%) of all lesion classifications in both relapsing-remitting and secondary progressive MS subtypes. The anterior subsection of the CC had the smallest proportional volume difference between subtypes (11%). Deep, temporal, and occipital white matter lesions, and occipital intracortical lesions were the strongest predictors of middle-posterior callosal atrophy (adjusted R = .54-.39, P < .01).

Conclusions: Both white matter and cortical lesions contribute to regional corpus callosal atrophy. The lobe-specific lesion topology does not fully explain the inhomogeneous CC atrophy.

Citing Articles

Differences in Brain Atrophy Pattern between People with Multiple Sclerosis and Systemic Diseases with Central Nervous System Involvement Based on Two-Dimensional Linear Measures.

Siger M, Wydra J, Wildner P, Podyma M, Puzio T, Matera K J Clin Med. 2024; 13(2).

PMID: 38256467 PMC: 10816254. DOI: 10.3390/jcm13020333.

Cortical and white matter lesion topology influences focal corpus callosum atrophy in multiple sclerosis.

Platten M, Ouellette R, Herranz E, Barletta V, Treaba C, Mainero C J Neuroimaging. 2022; 32(3):471-479.

PMID: 35165979 PMC: 9305945. DOI: 10.1111/jon.12977.

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