» Articles » PMID: 35162948

Structure, Function and Regulation of the Plasma Membrane Calcium Pump in Health and Disease

Overview
Journal Int J Mol Sci
Publisher MDPI
Date 2022 Feb 15
PMID 35162948
Authors
Affiliations
Soon will be listed here.
Abstract

In this review, I summarize the present knowledge of the structural and functional properties of the mammalian plasma membrane calcium pump (PMCA). It is outlined how the cellular expression of the different spliced isoforms of the four genes are regulated under normal and pathological conditions.

Citing Articles

A new regulation mechanism for KCNN4, the Ca-dependent K channel, by molecular interactions with the Capump PMCA4b.

Allegrini B, Mignotet M, Rapetti-Mauss R, Borgese F, Soriani O, Guizouarn H J Biol Chem. 2024; 301(2):108114.

PMID: 39716493 PMC: 11787511. DOI: 10.1016/j.jbc.2024.108114.


A role for plasma membrane Ca ATPases in regulation of cellular Ca homeostasis by sphingosine kinase-1.

Volk L, Bruun J, Trautmann S, Thomas D, Schwalm S, Pfeilschifter J Pflugers Arch. 2024; 476(12):1895-1911.

PMID: 39392480 PMC: 11582158. DOI: 10.1007/s00424-024-03027-7.


Calcium and Non-Penetrating Traumatic Brain Injury: A Proposal for the Implementation of an Early Therapeutic Treatment for Initial Head Insults.

ODay D Biomolecules. 2024; 14(7).

PMID: 39062567 PMC: 11274459. DOI: 10.3390/biom14070853.


Magnesium enhances aurintricarboxylic acid's inhibitory action on the plasma membrane Ca-ATPase.

Souto-Guevara C, Obiol D, Bruno C, Ferreira-Gomes M, Rossi J, Costabel M Sci Rep. 2024; 14(1):14693.

PMID: 38926545 PMC: 11208427. DOI: 10.1038/s41598-024-65465-8.


Analysis of cholesterol-recognition motifs of the plasma membrane Ca-ATPase.

Delgado-Coello B, Luna-Reyes I, Mendez-Acevedo K, Bravo-Martinez J, Montalvan-Sorrosa D, Mas-Oliva J J Bioenerg Biomembr. 2024; 56(3):205-219.

PMID: 38436904 PMC: 11116186. DOI: 10.1007/s10863-024-10010-5.


References
1.
Maune J, Klee C, Beckingham K . Ca2+ binding and conformational change in two series of point mutations to the individual Ca(2+)-binding sites of calmodulin. J Biol Chem. 1992; 267(8):5286-95. View

2.
Enyedi A, Strehler E . Regulation of apical membrane enrichment and retention of plasma membrane Ca ATPase splice variants by the PDZ-domain protein NHERF2. Commun Integr Biol. 2011; 4(3):340-3. PMC: 3187903. DOI: 10.4161/cib.4.3.15040. View

3.
Kenyon K, Bushong E, Mauer A, Strehler E, Weinberg R, Burette A . Cellular and subcellular localization of the neuron-specific plasma membrane calcium ATPase PMCA1a in the rat brain. J Comp Neurol. 2010; 518(16):3169-83. PMC: 2894304. DOI: 10.1002/cne.22409. View

4.
Brandt P, Neve R, Kammesheidt A, Rhoads R, Vanaman T . Analysis of the tissue-specific distribution of mRNAs encoding the plasma membrane calcium-pumping ATPases and characterization of an alternately spliced form of PMCA4 at the cDNA and genomic levels. J Biol Chem. 1992; 267(7):4376-85. View

5.
Okunade G, Miller M, Pyne G, Sutliff R, OConnor K, Neumann J . Targeted ablation of plasma membrane Ca2+-ATPase (PMCA) 1 and 4 indicates a major housekeeping function for PMCA1 and a critical role in hyperactivated sperm motility and male fertility for PMCA4. J Biol Chem. 2004; 279(32):33742-50. DOI: 10.1074/jbc.M404628200. View