A Subject-Tailored Variability-Based Platform for Overcoming the Plateau Effect in Sports Training: A Narrative Review

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2022 Feb 15

PMID 35162745

Authors

Ram Gelman

Marc Berg

Yaron Ilan

Affiliations

Soon will be listed here.

Abstract

The plateau effect in training is a significant obstacle for professional athletes and average subjects. It evolves from both the muscle-nerve-axis-associated performance and various cardiorespiratory parameters. Compensatory adaptation mechanisms contribute to a lack of continuous improvement with most exercise regimens. Attempts to overcome this plateau in exercise have been only partially successful, and it remains a significant unmet need in both healthy subjects and those suffering from chronic neuromuscular, cardiopulmonary, and metabolic diseases. Variability patterns characterize many biological processes, from cellular to organ levels. The present review discusses the significant obstacles in overcoming the plateau in training and establishes a platform to implement subject-tailored variability patterns to prevent and overcome this plateau in muscle and cardiorespiratory performance.

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References

Lodygin D, Flugel A . Intravital real-time analysis of T-cell activation in health and disease. Cell Calcium. 2017; 64:118-129. DOI: 10.1016/j.ceca.2016.12.007. View

Mitchell S, Roy K, Zangle T, Hoffmann A . Nongenetic origins of cell-to-cell variability in B lymphocyte proliferation. Proc Natl Acad Sci U S A. 2018; 115(12):E2888-E2897. PMC: 5866559. DOI: 10.1073/pnas.1715639115. View

Mehdizadeh A, Barzegar M, Negargar S, Yahyavi A, Raeisi S . The current and emerging therapeutic approaches in drug-resistant epilepsy management. Acta Neurol Belg. 2019; 119(2):155-162. DOI: 10.1007/s13760-019-01120-8. View

Nyberg S, Berg O, Helgerud J, Wang E . Blood flow regulation and oxygen uptake during high-intensity forearm exercise. J Appl Physiol (1985). 2017; 122(4):907-917. DOI: 10.1152/japplphysiol.00983.2016. View

Hatef B, Bahrpeyma F, Mohajeri Tehrani M . The comparison of muscle strength and short-term endurance in the different periods of type 2 diabetes. J Diabetes Metab Disord. 2014; 13(1):22. PMC: 3929159. DOI: 10.1186/2251-6581-13-22. View

Racinais S, Buchheit M, Girard O . Breakpoints in ventilation, cerebral and muscle oxygenation, and muscle activity during an incremental cycling exercise. Front Physiol. 2014; 5:142. PMC: 3990045. DOI: 10.3389/fphys.2014.00142. View

Ilan Y . Microtubules: From understanding their dynamics to using them as potential therapeutic targets. J Cell Physiol. 2018; 234(6):7923-7937. DOI: 10.1002/jcp.27978. View

Wada Y, Kondo I, Sonoda S, Miyasaka H, Teranishi T, Nagai S . Preliminary trial to increase gait velocity with high speed treadmill training for patients with hemiplegia. Am J Phys Med Rehabil. 2010; 89(8):683-7. DOI: 10.1097/PHM.0b013e3181e29d27. View

Ishay Y, Kolben Y, Kessler A, Ilan Y . Role of circadian rhythm and autonomic nervous system in liver function: a hypothetical basis for improving the management of hepatic encephalopathy. Am J Physiol Gastrointest Liver Physiol. 2021; 321(4):G400-G412. DOI: 10.1152/ajpgi.00186.2021. View

10.

Gueta I, Markovits N, Yarden-Bilavsky H, Raichlin E, Freimark D, Lavee J . Intrapatient variability in tacrolimus trough levels after solid organ transplantation varies at different postoperative time periods. Am J Transplant. 2018; 19(2):611. DOI: 10.1111/ajt.15134. View

11.

Boone J, Vandekerckhove K, Coomans I, Prieur F, Bourgois J . An integrated view on the oxygenation responses to incremental exercise at the brain, the locomotor and respiratory muscles. Eur J Appl Physiol. 2016; 116(11-12):2085-2102. DOI: 10.1007/s00421-016-3468-x. View

12.

Leino A, King E, Jiang W, Vinks A, Klawitter J, Christians U . Assessment of tacrolimus intrapatient variability in stable adherent transplant recipients: Establishing baseline values. Am J Transplant. 2018; 19(5):1410-1420. DOI: 10.1111/ajt.15199. View

13.

Frank J, Lovejoy T, Becker W, Morasco B, Koenig C, Hoffecker L . Patient Outcomes in Dose Reduction or Discontinuation of Long-Term Opioid Therapy: A Systematic Review. Ann Intern Med. 2017; 167(3):181-191. DOI: 10.7326/M17-0598. View

14.

Finn H, Brennan S, Gonano B, Knox M, Ryan R, Siegler J . Muscle activation does not increase after a fatigue plateau is reached during 8 sets of resistance exercise in trained individuals. J Strength Cond Res. 2014; 28(5):1226-34. DOI: 10.1097/JSC.0000000000000226. View

15.

Spee R, Niemeijer V, Wessels B, Jansen J, Wijn P, Doevendans P . Characterization of exercise limitations by evaluating individual cardiac output patterns: a prospective cohort study in patients with chronic heart failure. BMC Cardiovasc Disord. 2015; 15:57. PMC: 4476170. DOI: 10.1186/s12872-015-0057-6. View

16.

Hebisz P, Hebisz R, Borkowski J, Zaton M . Time of VO(2)max plateau and post-exercise oxygen consumption during incremental exercise testing in young mountain bike and road cyclists. Physiol Res. 2018; 67(5):711-719. DOI: 10.33549/physiolres.933744. View

17.

Isahy Y, Ilan Y . Improving the long-term response to antidepressants by establishing an individualized platform based on variability and chronotherapy. Int J Clin Pharmacol Ther. 2021; 59(12):768-774. DOI: 10.5414/CP204000. View

18.

Gelman R, Bayatra A, Kessler A, Schwartz A, Ilan Y . Targeting SARS-CoV-2 receptors as a means for reducing infectivity and improving antiviral and immune response: an algorithm-based method for overcoming resistance to antiviral agents. Emerg Microbes Infect. 2020; 9(1):1397-1406. PMC: 7473106. DOI: 10.1080/22221751.2020.1776161. View

19.

Mezza T, Cinti F, Assunta Cefalo C, Pontecorvi A, Kulkarni R, Giaccari A . β-Cell Fate in Human Insulin Resistance and Type 2 Diabetes: A Perspective on Islet Plasticity. Diabetes. 2019; 68(6):1121-1129. PMC: 6905483. DOI: 10.2337/db18-0856. View

20.

Buckle A, Borg N . Integrating Experiment and Theory to Understand TCR-pMHC Dynamics. Front Immunol. 2018; 9:2898. PMC: 6293202. DOI: 10.3389/fimmu.2018.02898. View