Biosensor-enabled Pathway Optimization in Metabolic Engineering

Overview

Journal Curr Opin Biotechnol

Publisher Elsevier

Specialty Biotechnology

Date 2022 Feb 14

PMID 35158314

Authors

Yuxi Teng

Jianli Zhang

Tian Jiang

Yusong Zou

Xinyu Gong

Yajun Yan

Affiliations

Soon will be listed here.

Abstract

Microbes can convert inexpensive renewable substrates to valuable metabolites by their natural metabolic pathways. To maximize the productivity, the pathways yet require further optimization, which remains challenging for our limited knowledge of complex biology. Genetically encoded biosensors are able to detect metabolite concentrations or environmental changes and transfer these inputs to measurable or actionable outputs, thus providing enabling regulation and monitoring tools for complicated pathway optimization. Here, we review recent advances in biosensor-mediated dynamic regulation and strain screening for the highest microbial production of diverse desirable products.

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