Therapeutic Applications of Curcumin in Diabetes: A Review and Perspective

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2022 Feb 14

PMID 35155670

Authors

Cristina Quispe

Jesus Herrera-Bravo

Zeeshan Javed

Khushbukhat Khan

Shahid Raza

Zehra Gulsunoglu-Konuskan

Sevgi Durna Dastan

Oksana Sytar

Miquel Martorell

Javad Sharifi-Rad

Daniela Calina

Affiliations

Soon will be listed here.

Abstract

Diabetes is a metabolic disease with multifactorial causes which requires lifelong drug therapy as well as lifestyle changes. There is now growing scientific evidence to support the effectiveness of the use of herbal supplements in the prevention and control of diabetes. Curcumin is one of the most studied bioactive components of traditional medicine, but its physicochemical characteristics are represented by low solubility, poor absorption, and low efficacy. Nanotechnology-based pharmaceutical formulations can help overcome the problems of reduced bioavailability of curcumin and increase its antidiabetic effects. The objectives of this review were to review the effects of nanocurcumin on DM and to search for databases such as PubMed/MEDLINE and ScienceDirect. The results showed that the antidiabetic activity of nanocurcumin is due to complex pharmacological mechanisms by reducing the characteristic hyperglycemia of DM. In light of these results, nanocurcumin may be considered as potential agent in the pharmacotherapeutic management of patients with diabetes.

Citing Articles

Enhancing Periodontal Ligament Regeneration via PDLSC Delivery Using Electrospun PCL/Collagen/Cellulose Acetate Scaffolds and Collagen Hydrogel Incorporated with Curcumin-Loaded ZIF-8 Nanoparticles.

Lan X, Wang Y, Yin M Int J Nanomedicine. 2025; 20:887-906.

PMID: 39867310 PMC: 11761539. DOI: 10.2147/IJN.S492274.

Bioactive Silk Revolution: Harnessing Curcuminoid Dye and Chitosan for Superior Antimicrobial Defence and UV Shielding.

Do K, Ahsan T, Wahab A, Tayyab M, Yin X, Pan N Pharmaceutics. 2025; 16(12.

PMID: 39771490 PMC: 11728638. DOI: 10.3390/pharmaceutics16121510.

Comparison of the efficacy of curcumin and its nano formulation on dexamethasone-induced hepatic steatosis, dyslipidemia, and hyperglycemia in Wistar rats.

Hamed A, Elbahy D, Ahmed A, Thabet S, Refaei R, Ragab I Heliyon. 2025; 10(24):e41043.

PMID: 39759349 PMC: 11696662. DOI: 10.1016/j.heliyon.2024.e41043.

Diosmin: A promising phytochemical for functional foods, nutraceuticals and cancer therapy.

Rahman L, Khalil A, Ahsan Shahid S, Shinwari Z, Almarhoon Z, Alalmaie A Food Sci Nutr. 2024; 12(9):6070-6092.

PMID: 39554345 PMC: 11561841. DOI: 10.1002/fsn3.4271.

Analysis of the management and therapeutic performance of diabetes mellitus employing special target.

Sun H, Lin X World J Diabetes. 2024; 14(12):1721-1737.

PMID: 38222785 PMC: 10784800. DOI: 10.4239/wjd.v14.i12.1721.

References

Noorafshan A, Ashkani-Esfahani S . A review of therapeutic effects of curcumin. Curr Pharm Des. 2012; 19(11):2032-46. View

Stohs S, Ji J, Bucci L, Preuss H . A Comparative Pharmacokinetic Assessment of a Novel Highly Bioavailable Curcumin Formulation with 95% Curcumin: A Randomized, Double-Blind, Crossover Study. J Am Coll Nutr. 2017; 37(1):51-59. DOI: 10.1080/07315724.2017.1358118. View

Salehi B, Calina D, Docea A, Koirala N, Aryal S, Lombardo D . Curcumin's Nanomedicine Formulations for Therapeutic Application in Neurological Diseases. J Clin Med. 2020; 9(2). PMC: 7074182. DOI: 10.3390/jcm9020430. View

Choi Y, Kim W, Lee J, Youn S, Lee H, Baik M . Enhanced Antioxidant Capacity of Puffed Turmeric ( L.) by High Hydrostatic Pressure Extraction (HHPE) of Bioactive Compounds. Foods. 2020; 9(11). PMC: 7699201. DOI: 10.3390/foods9111690. View

Devadasu V, Wadsworth R, Kumar M . Protective effects of nanoparticulate coenzyme Q10 and curcumin on inflammatory markers and lipid metabolism in streptozotocin-induced diabetic rats: a possible remedy to diabetic complications. Drug Deliv Transl Res. 2015; 1(6):448-55. DOI: 10.1007/s13346-011-0041-3. View

Pistone S, Goycoolea F, Young A, Smistad G, Hiorth M . Formulation of polysaccharide-based nanoparticles for local administration into the oral cavity. Eur J Pharm Sci. 2016; 96:381-389. DOI: 10.1016/j.ejps.2016.10.012. View

Liu J, Chen Z, Wang J, Li R, Li T, Chang M . Encapsulation of Curcumin Nanoparticles with MMP9-Responsive and Thermos-Sensitive Hydrogel Improves Diabetic Wound Healing. ACS Appl Mater Interfaces. 2018; 10(19):16315-16326. DOI: 10.1021/acsami.8b03868. View

Rastogi M, Saha R, Alexander A, Singhvi G, Puri A, Dubey S . Role of stealth lipids in nanomedicine-based drug carriers. Chem Phys Lipids. 2021; 235:105036. DOI: 10.1016/j.chemphyslip.2020.105036. View

Kesharwani P, Xie L, Banerjee S, Mao G, Padhye S, Sarkar F . Hyaluronic acid-conjugated polyamidoamine dendrimers for targeted delivery of 3,4-difluorobenzylidene curcumin to CD44 overexpressing pancreatic cancer cells. Colloids Surf B Biointerfaces. 2015; 136:413-23. DOI: 10.1016/j.colsurfb.2015.09.043. View

10.

Tong F, Chai R, Jiang H, Dong B . In vitro/vivo drug release and anti-diabetic cardiomyopathy properties of curcumin/PBLG-PEG-PBLG nanoparticles. Int J Nanomedicine. 2018; 13:1945-1962. PMC: 5892954. DOI: 10.2147/IJN.S153763. View

11.

Wickenberg J, Ingemansson S, Hlebowicz J . Effects of Curcuma longa (turmeric) on postprandial plasma glucose and insulin in healthy subjects. Nutr J. 2010; 9:43. PMC: 2964546. DOI: 10.1186/1475-2891-9-43. View

12.

Shamsi-Goushki A, Mortazavi Z, Mirshekar M, Mohammadi M, Moradi-Kor N, Jafari-Maskouni S . Comparative Effects of Curcumin versus Nano-Curcumin on Insulin Resistance, Serum Levels of Apelin and Lipid Profile in Type 2 Diabetic Rats. Diabetes Metab Syndr Obes. 2020; 13:2337-2346. PMC: 7342486. DOI: 10.2147/DMSO.S247351. View

13.

Hossain R, Quispe C, Herrera-Bravo J, Islam M, Sarkar C, Islam M . Chemical Composition and Therapeutic Potential: A Literature-Based Review. Oxid Med Cell Longev. 2022; 2021:1602437. PMC: 8727140. DOI: 10.1155/2021/1602437. View

14.

Zheng J, Cheng J, Zheng S, Feng Q, Xiao X . Curcumin, A Polyphenolic Curcuminoid With Its Protective Effects and Molecular Mechanisms in Diabetes and Diabetic Cardiomyopathy. Front Pharmacol. 2018; 9:472. PMC: 5954291. DOI: 10.3389/fphar.2018.00472. View

15.

Chen Y, Lu Y, Lee R, Xiang G . Nano Encapsulated Curcumin: And Its Potential for Biomedical Applications. Int J Nanomedicine. 2020; 15:3099-3120. PMC: 7200256. DOI: 10.2147/IJN.S210320. View

16.

Bulboaca A, Boarescu P, Bolboaca S, Blidaru M, Festila D, Dogaru G . Comparative Effect Of Curcumin Versus Liposomal Curcumin On Systemic Pro-Inflammatory Cytokines Profile, MCP-1 And RANTES In Experimental Diabetes Mellitus. Int J Nanomedicine. 2019; 14:8961-8972. PMC: 6873975. DOI: 10.2147/IJN.S226790. View

17.

Suvarna R, Shenoy R, Hadapad B, Nayak A . Effectiveness of polyherbal formulations for the treatment of type 2 Diabetes mellitus - A systematic review and meta-analysis. J Ayurveda Integr Med. 2021; 12(1):213-222. PMC: 8039362. DOI: 10.1016/j.jaim.2020.11.002. View

18.

Salehi B, Sharifi-Rad J, Cappellini F, Reiner Z, Zorzan D, Imran M . The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action. Front Pharmacol. 2020; 11:1300. PMC: 7479177. DOI: 10.3389/fphar.2020.01300. View

19.

Khan J, Alexander A, Ajazuddin , Saraf S, Saraf S . Recent advances and future prospects of phyto-phospholipid complexation technique for improving pharmacokinetic profile of plant actives. J Control Release. 2013; 168(1):50-60. DOI: 10.1016/j.jconrel.2013.02.025. View

20.

Alizadeh M, Kheirouri S . Curcumin reduces malondialdehyde and improves antioxidants in humans with diseased conditions: a comprehensive meta-analysis of randomized controlled trials. Biomedicine (Taipei). 2019; 9(4):23. PMC: 6855189. DOI: 10.1051/bmdcn/2019090423. View