Protective Effects of Nanoparticulate Coenzyme Q10 and Curcumin on Inflammatory Markers and Lipid Metabolism in Streptozotocin-induced Diabetic Rats: a Possible Remedy to Diabetic Complications

Overview

Journal Drug Deliv Transl Res

Publisher Springer

Specialty Pharmacology

Date 2015 Mar 20

PMID 25786365

Citations 19

Authors

Venkat Ratnam Devadasu

Roger M Wadsworth

M N V Ravi Kumar

Affiliations

Soon will be listed here.

Abstract

Diabetes and its complications have been linked to increased levels of free radicals and systemic pro-inflammatory cytokines and to an altered lipid profile. Coenzyme Q10 and curcumin are potent antioxidants and anti-inflammatory agents but are underutilized clinically because of their poor bioavailability when administered orally. We have recently developed poly(D,L-lactic-co-glycolic acid)-based nanoparticles in which we have encapsulated coenzyme Q10 and curcumin to increase the oral bioavailability and therapeutic efficacy of the antioxidant molecules. These formulations when tested in streptozotocin-induced diabetic rats demonstrated protective effects on inflammatory markers as well as lipid metabolism. Coenzyme Q10 nanoparticulates reduced only C-reactive protein levels, whereas curcumin nanoparticles reduced levels of C-reactive protein, interleukin-6 and tumor necrosis factor-α. Administration of both nanoparticulates resulted in significant reductions of plasma triglycerides and total cholesterol and an increase in high-density lipoprotein cholesterol. Together, these data indicate the promise of coenzyme Q10 and curcumin in diabetes when delivered through nanoparticulate formulations.

Citing Articles

Evaluation of the anti-diabetic and anti-inflammatory potentials of curcumin nanoparticle in diabetic rat induced by streptozotocin.

Alrashdi B, Askar H, Germoush M, Fouda M, Abdel-Farid I, Massoud D Open Vet J. 2025; 14(12):3375-3387.

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Revolutionizing Hyperlipidemia Treatment: Nanoencapsulated CoQ10 and Selenium Combat Simvastatin-Induced Myopathy and Insulin Resistance in Rats.

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Ameliorative Effects of Curcumin on Type 2 Diabetes Mellitus.

Gu Y, Niu Q, Zhang Q, Zhao Y Molecules. 2024; 29(12).

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Glucose-Responsive Microgel Comprising Conventional Insulin and Curcumin-Laden Nanoparticles: a Potential Combination for Diabetes Management.

Heyns I, Davis G, Ganugula R, Kumar M, Arora M AAPS J. 2023; 25(4):72.

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Oxidative Stress in Diabetic Peripheral Neuropathy: Pathway and Mechanism-Based Treatment.

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