Effect of Lavender ( L.) Syrup on Olfactory Dysfunction in COVID-19 Infection: A Pilot Controlled Clinical Trial

Overview

Journal Avicenna J Phytomed

Publisher Mashhad University of Medical Sciences

Date 2022 Feb 11

PMID 35145890

Authors

Fataneh Hashem-Dabaghian

Sadegh Ali Azimi

Mohsen Bahrami

Seied-Amirhossein Latifi

Ayesheh Enayati

Marzieh Qaraaty

Affiliations

Soon will be listed here.

Abstract

Objective: The effect of lavender syrup on COVID-19-induced olfactory dysfunction OD has been assessed in this study.

Materials And Methods: This pilot clinical trial was conducted in Gonbad-E-Kavoos (Golestan province, Iran). Twenty-three outpatients with COVID-19 and OD in lavender group took 9 ml of lavender syrup/bid for 3 weeks along with the standard COVID-19 treatments and 20 patients in control group took only standard COVID-19 treatments. The severity of OD was assessed by the visual analogue scale (VAS). Data analysis was performed by Friedman and Mann-Whitney tests using SPSS software.

Results: The mean± standard deviation of age was 36.6±9.1, and 42.6±10.4 years (p=0.05), and the duration of symptoms was 7.4±3.5, and 7.5±3.4 days (p=0.98) in the lavender and control group, respectively. The VAS score for OD decreased from 6.8±3.04 to 0.26±0.86 in the lavender group and from 5.3±3.4 to 1±2.61 in the control group. Although, VAS for OD was significantly decreased in both groups (p<0.001), the amount of VAS decrease was 6.6±2.9 scores in the lavender group, and 4.3±4 in the control group (p=0.03). No side effects were observed in the lavender group.

Conclusion: The present study showed that lavender syrup is an effective treatment for COVID-19-induced OD. It is suggested to conduct further studies with larger sample size.

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References

Klopfenstein T, Kadiane-Oussou N, Toko L, Royer P, Lepiller Q, Gendrin V . Features of anosmia in COVID-19. Med Mal Infect. 2020; 50(5):436-439. PMC: 7162775. DOI: 10.1016/j.medmal.2020.04.006. View

Doulaptsi M, Prokopakis E, Seys S, Pugin B, Steelant B, Hellings P . Visual analogue scale for sino-nasal symptoms severity correlates with sino-nasal outcome test 22: paving the way for a simple outcome tool of CRS burden. Clin Transl Allergy. 2018; 8:32. PMC: 6120084. DOI: 10.1186/s13601-018-0219-6. View

Cavanagh H, Wilkinson J . Biological activities of lavender essential oil. Phytother Res. 2002; 16(4):301-8. DOI: 10.1002/ptr.1103. View

Goncalves S, Goldstein B . Pathophysiology of Olfactory Disorders and Potential Treatment Strategies. Curr Otorhinolaryngol Rep. 2016; 4(2):115-121. PMC: 4982703. DOI: 10.1007/s40136-016-0113-5. View

Spinato G, Fabbris C, Polesel J, Cazzador D, Borsetto D, Hopkins C . Alterations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection. JAMA. 2020; 323(20):2089-2090. PMC: 7177631. DOI: 10.1001/jama.2020.6771. View

Han A, Mukdad L, Long J, Lopez I . Anosmia in COVID-19: Mechanisms and Significance. Chem Senses. 2020; . PMC: 7449368. DOI: 10.1093/chemse/bjaa040. View

Whitcroft K, Hummel T . Olfactory Dysfunction in COVID-19: Diagnosis and Management. JAMA. 2020; 323(24):2512-2514. DOI: 10.1001/jama.2020.8391. View

da Silva J, Figueiredo P, Byler K, Setzer W . Essential Oils as Antiviral Agents. Potential of Essential Oils to Treat SARS-CoV-2 Infection: An Investigation. Int J Mol Sci. 2020; 21(10). PMC: 7279430. DOI: 10.3390/ijms21103426. View

Gengler I, Wang J, Speth M, Sedaghat A . Sinonasal pathophysiology of SARS-CoV-2 and COVID-19: A systematic review of the current evidence. Laryngoscope Investig Otolaryngol. 2020; 5(3):354-359. PMC: 7262250. DOI: 10.1002/lio2.384. View

10.

Borsetto D, Hopkins C, Philips V, Obholzer R, Tirelli G, Polesel J . Self-reported alteration of sense of smell or taste in patients with COVID-19: a systematic review and meta-analysis on 3563 patients. Rhinology. 2020; 58(5):430-436. DOI: 10.4193/Rhin20.185. View

11.

Brann D, Tsukahara T, Weinreb C, Lipovsek M, Van den Berge K, Gong B . Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia. Sci Adv. 2020; 6(31). PMC: 10715684. DOI: 10.1126/sciadv.abc5801. View

12.

Sungnak W, Huang N, Becavin C, Berg M, Queen R, Litvinukova M . SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat Med. 2020; 26(5):681-687. PMC: 8637938. DOI: 10.1038/s41591-020-0868-6. View

13.

Laurendon T, Radulesco T, Mugnier J, Gerault M, Chagnaud C, El Ahmadi A . Bilateral transient olfactory bulb edema during COVID-19-related anosmia. Neurology. 2020; 95(5):224-225. DOI: 10.1212/WNL.0000000000009850. View

14.

Acikalin A, Gulen M, Kara B, Icme F, Cagliyan C, Satar S . Anticholinergic syndrome and supraventricular tachycardia caused by lavender tea toxicity. Keio J Med. 2012; 61(2):66-8. DOI: 10.2302/kjm.61.66. View

15.

Koulivand P, Khaleghi Ghadiri M, Gorji A . Lavender and the nervous system. Evid Based Complement Alternat Med. 2013; 2013:681304. PMC: 3612440. DOI: 10.1155/2013/681304. View

16.

Silva G, Luft C, Lunardelli A, Amaral R, Melo D, Donadio M . Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil. An Acad Bras Cienc. 2015; 87(2 Suppl):1397-408. DOI: 10.1590/0001-3765201520150056. View

17.

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y . Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; 395(10223):497-506. PMC: 7159299. DOI: 10.1016/S0140-6736(20)30183-5. View

18.

Basch E, Foppa I, Liebowitz R, Nelson J, Smith M, Sollars D . Lavender (Lavandula angustifolia Miller). J Herb Pharmacother. 2004; 4(2):63-78. View

19.

Hajhashemi V, Ghannadi A, Sharif B . Anti-inflammatory and analgesic properties of the leaf extracts and essential oil of Lavandula angustifolia Mill. J Ethnopharmacol. 2003; 89(1):67-71. DOI: 10.1016/s0378-8741(03)00234-4. View

20.

Boesveldt S, Postma E, Boak D, Welge-Luessen A, Schopf V, Mainland J . Anosmia-A Clinical Review. Chem Senses. 2017; 42(7):513-523. PMC: 5863566. DOI: 10.1093/chemse/bjx025. View