Medication Non-adherence As a Cause of Apixaban Failure in Venous Thromboembolism: The Importance of Pharmacist Medication Reconciliation

Overview

Journal Clin Case Rep

Date 2022 Feb 10

PMID 35140953

Authors

Trisha E Jethwa

Kaitlin M Moran

Michael J Maniaci

Affiliations

Soon will be listed here.

Abstract

Venous thromboembolism is often treated with direct oral anticoagulants. In order for direct oral anticoagulants to be effective, patients must adhere to a specific dosing strategy. We report a case of apixaban failure, the clinical workup that ensued, and the eventual discovery of unsuccessful medication adherence as the cause.

Citing Articles

Trust but verify: A case report of unintended medication omission.

Bryant A, Pitman S, Lessing J Clin Case Rep. 2023; 11(1):e6800.

PMID: 36619493 PMC: 9810832. DOI: 10.1002/ccr3.6800.

Medication non-adherence as a cause of apixaban failure in venous thromboembolism: The importance of pharmacist medication reconciliation.

Jethwa T, Moran K, Maniaci M Clin Case Rep. 2022; 10(2):e05338.

PMID: 35140953 PMC: 8811178. DOI: 10.1002/ccr3.5338.

References

Jethwa T, Moran K, Maniaci M . Medication non-adherence as a cause of apixaban failure in venous thromboembolism: The importance of pharmacist medication reconciliation. Clin Case Rep. 2022; 10(2):e05338. PMC: 8811178. DOI: 10.1002/ccr3.5338. View

Kripalani S, Jackson A, Schnipper J, Coleman E . Promoting effective transitions of care at hospital discharge: a review of key issues for hospitalists. J Hosp Med. 2007; 2(5):314-23. DOI: 10.1002/jhm.228. View

Gadallah A, McGinnis B, Nguyen B, Olson J . Assessing the impact of virtual medication history technicians on medication reconciliation discrepancies. Int J Clin Pharm. 2021; 43(5):1404-1411. DOI: 10.1007/s11096-021-01267-6. View

Kajy M, Mathew A, Ramappa P . Treatment Failures of Direct Oral Anticoagulants. Am J Ther. 2019; 28(1):e87-e95. DOI: 10.1097/MJT.0000000000001083. View

Klingbeil C, Gibson C . The Teach Back Project: A System-wide Evidence Based Practice Implementation. J Pediatr Nurs. 2018; 42:81-85. DOI: 10.1016/j.pedn.2018.06.002. View

Griffey R, Shin N, Jones S, Aginam N, Gross M, Kinsella Y . The impact of teach-back on comprehension of discharge instructions and satisfaction among emergency patients with limited health literacy: A randomized, controlled study. J Commun Healthc. 2015; 8(1):10-21. PMC: 4659395. DOI: 10.1179/1753807615Y.0000000001. View

Michota F . Transitions of care in anticoagulated patients. J Multidiscip Healthc. 2013; 6:215-28. PMC: 3693821. DOI: 10.2147/JMDH.S44068. View

Aryal M, Gosain R, Donato A, Yu H, Katel A, Bhandari Y . Systematic review and meta-analysis of the efficacy and safety of apixaban compared to rivaroxaban in acute VTE in the real world. Blood Adv. 2019; 3(15):2381-2387. PMC: 6693001. DOI: 10.1182/bloodadvances.2019000572. View

Heit J, Spencer F, White R . The epidemiology of venous thromboembolism. J Thromb Thrombolysis. 2016; 41(1):3-14. PMC: 4715842. DOI: 10.1007/s11239-015-1311-6. View

10.

Burnett A, Mahan C, Vazquez S, Oertel L, Garcia D, Ansell J . Guidance for the practical management of the direct oral anticoagulants (DOACs) in VTE treatment. J Thromb Thrombolysis. 2016; 41(1):206-32. PMC: 4715848. DOI: 10.1007/s11239-015-1310-7. View

11.

Makam R, Hoaglin D, McManus D, Wang V, Gore J, Spencer F . Efficacy and safety of direct oral anticoagulants approved for cardiovascular indications: Systematic review and meta-analysis. PLoS One. 2018; 13(5):e0197583. PMC: 5967718. DOI: 10.1371/journal.pone.0197583. View

12.

Kornburger C, Gibson C, Sadowski S, Maletta K, Klingbeil C . Using "teach-back" to promote a safe transition from hospital to home: an evidence-based approach to improving the discharge process. J Pediatr Nurs. 2012; 28(3):282-91. DOI: 10.1016/j.pedn.2012.10.007. View

13.

Johnston R, Saulnier L, Gould O . Best possible medication history in the emergency department: comparing pharmacy technicians and pharmacists. Can J Hosp Pharm. 2012; 63(5):359-65. PMC: 2999367. DOI: 10.4212/cjhp.v63i5.947. View