A Mutation Affecting the Sigma Subunit of RNA Polymerase Changes Transcriptional Specificity

Overview

Journal Nature

Specialty Science

Date 1978 Jun 1

PMID 351406

Citations 35

Authors

A A Travers

R Buckland

M Goman

S S Le Grice

J G Scaife

Affiliations

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Abstract

The RNA polymerase mutation, alt-1, affects the sigma subunit and alters the in vitro selectivity of RNA polymerase to parallel the in vivo phenotype. We propose that the mutation changes the distribution of functionally distinct polymerase isomers.

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