CCAAT Enhancer Binding Protein Gamma (C/EBP-γ): An Understudied Transcription Factor

Overview

Journal Adv Biol Regul

Publisher Elsevier

Specialties Biochemistry
Molecular Biology

Date 2022 Feb 5

PMID 35121409

Authors

Zachary Renfro

Bryan E White

Kimberly E Stephens

Affiliations

Soon will be listed here.

Abstract

The CCAAT enhancer binding protein (C/EBP) family of transcription factors are important transcriptional mediators of a wide range of physiologic processes. C/EBP-γ is the shortest C/EBP protein and lacks a canonical activation domain for the recruitment of transcriptional machinery. Despite its ubiquitous expression and ability to dimerize with other C/EBP proteins, C/EBP-γ has been studied far less than other C/EBP proteins, and, to our knowledge, no review of its functions has been written. This review seeks to integrate the current knowledge about C/EBP-γ and its physiologic roles, especially in cell proliferation, the integrated stress response, oncogenesis, hematopoietic and nervous system development, and metabolism, as well as to identify areas for future research.

Citing Articles

How Chromatin Motor Complexes Influence the Nuclear Architecture: A Review of Chromatin Organization, Cohesins, and Condensins with a Focus on .

Chawla B, Csankovszki G DNA (Basel). 2024; 4(1):84-103.

PMID: 39726802 PMC: 11671135. DOI: 10.3390/dna4010005.

Human RP105 monoclonal antibody enhances antigen-specific antibody production in unique culture conditions.

Yamazaki T, Iwasaki K, Tomono S, Imai M, Miwa Y, Shizuku M iScience. 2024; 27(9):110649.

PMID: 39246445 PMC: 11380396. DOI: 10.1016/j.isci.2024.110649.

Transcriptomic landscapes reveal development-related physiological processes in the two-spotted spider mite, Tetranychus urticae.

Gao S, Niu Y, Chen L, Chen M, Bing X, Hong X Exp Appl Acarol. 2024; 93(4):743-759.

PMID: 39150623 DOI: 10.1007/s10493-024-00956-x.

The Function and Mechanism of Long Noncoding RNAs in Adipogenic Differentiation.

Chen J, Pan Y, Lu Y, Fang X, Ma T, Chen X Genes (Basel). 2024; 15(7).

PMID: 39062654 PMC: 11275360. DOI: 10.3390/genes15070875.

Gene regulatory network topology governs resistance and treatment escape in glioma stem-like cells.

Park J, Hothi P, de Lomana A, Pan M, Calder R, Turkarslan S Sci Adv. 2024; 10(23):eadj7706.

PMID: 38848360 PMC: 11160475. DOI: 10.1126/sciadv.adj7706.

References

Hattori T, Ohoka N, Inoue Y, Hayashi H, Onozaki K . C/EBP family transcription factors are degraded by the proteasome but stabilized by forming dimer. Oncogene. 2003; 22(9):1273-80. DOI: 10.1038/sj.onc.1206204. View

Vinson C, Hai T, Boyd S . Dimerization specificity of the leucine zipper-containing bZIP motif on DNA binding: prediction and rational design. Genes Dev. 1993; 7(6):1047-58. DOI: 10.1101/gad.7.6.1047. View

Sikalidis A, Lee J, Stipanuk M . Gene expression and integrated stress response in HepG2/C3A cells cultured in amino acid deficient medium. Amino Acids. 2010; 41(1):159-71. PMC: 3119335. DOI: 10.1007/s00726-010-0571-x. View

Zafarana G, Rottier R, Grosveld F, Philipsen S . Erythroid overexpression of C/EBPgamma in transgenic mice affects gamma-globin expression and fetal liver erythropoiesis. EMBO J. 2000; 19(21):5856-63. PMC: 305797. DOI: 10.1093/emboj/19.21.5856. View

Lou Y . CEBPA-CEBPG axis as a novel promising therapeutic target in acute myeloid leukemia. Acta Pharmacol Sin. 2013; 34(2):185-6. PMC: 4011613. DOI: 10.1038/aps.2012.191. View

Blomquist T, Brown R, Crawford E, de la Serna I, Williams K, Yoon Y . CEBPG Exhibits Allele-Specific Expression in Human Bronchial Epithelial Cells. Gene Regul Syst Bio. 2013; 7:125-38. PMC: 3712557. DOI: 10.4137/GRSB.S11879. View

Cooper C, Berrier A, Roman C, Calame K . Limited expression of C/EBP family proteins during B lymphocyte development. Negative regulator Ig/EBP predominates early and activator NF-IL-6 is induced later. J Immunol. 1994; 153(11):5049-58. View

Iwama A, Osawa M, Hirasawa R, Uchiyama N, Kaneko S, Onodera M . Reciprocal roles for CCAAT/enhancer binding protein (C/EBP) and PU.1 transcription factors in Langerhans cell commitment. J Exp Med. 2002; 195(5):547-58. PMC: 2193769. DOI: 10.1084/jem.20011465. View

Shi H, Niimi A, Takeuchi T, Shiogama K, Mizutani Y, Kajino T . CEBPγ facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation. Cancer Sci. 2021; 112(7):2770-2780. PMC: 8253294. DOI: 10.1111/cas.14928. View

10.

Blalock W, Grimaldi C, Fala F, Follo M, Horn S, Basecke J . PKR activity is required for acute leukemic cell maintenance and growth: a role for PKR-mediated phosphatase activity to regulate GSK-3 phosphorylation. J Cell Physiol. 2009; 221(1):232-41. DOI: 10.1002/jcp.21848. View

11.

Alberich-Jorda M, Wouters B, Balastik M, Shapiro-Koss C, Zhang H, Di Ruscio A . C/EBPγ deregulation results in differentiation arrest in acute myeloid leukemia. J Clin Invest. 2012; 122(12):4490-504. PMC: 3533560. DOI: 10.1172/JCI65102. View

12.

Huggins C, Malik R, Lee S, Salotti J, Thomas S, Martin N . C/EBPγ suppresses senescence and inflammatory gene expression by heterodimerizing with C/EBPβ. Mol Cell Biol. 2013; 33(16):3242-58. PMC: 3753923. DOI: 10.1128/MCB.01674-12. View

13.

Follo M, Mongiorgi S, Finelli C, Clissa C, Ramazzotti G, Fiume R . Nuclear inositide signaling in myelodysplastic syndromes. J Cell Biochem. 2010; 109(6):1065-71. DOI: 10.1002/jcb.22483. View

14.

Bjerregaard M, Jurlander J, Klausen P, Borregaard N, Cowland J . The in vivo profile of transcription factors during neutrophil differentiation in human bone marrow. Blood. 2003; 101(11):4322-32. DOI: 10.1182/blood-2002-03-0835. View

15.

Williams M, Amaral F, Simeoni F, Somervaille T . A stress-responsive enhancer induces dynamic drug resistance in acute myeloid leukemia. J Clin Invest. 2019; 130(3):1217-1232. PMC: 7269587. DOI: 10.1172/JCI130809. View

16.

Tjahjono E, Kirienko N . A conserved mitochondrial surveillance pathway is required for defense against Pseudomonas aeruginosa. PLoS Genet. 2017; 13(6):e1006876. PMC: 5510899. DOI: 10.1371/journal.pgen.1006876. View

17.

Cooper C, Henderson A, Artandi S, Avitahl N, Calame K . Ig/EBP (C/EBP gamma) is a transdominant negative inhibitor of C/EBP family transcriptional activators. Nucleic Acids Res. 1995; 23(21):4371-7. PMC: 307392. DOI: 10.1093/nar/23.21.4371. View

18.

Crawford E, Blomquist T, Mullins D, Yoon Y, Hernandez D, Al-Bagdhadi M . CEBPG regulates ERCC5/XPG expression in human bronchial epithelial cells and this regulation is modified by E2F1/YY1 interactions. Carcinogenesis. 2007; 28(12):2552-9. DOI: 10.1093/carcin/bgm214. View

19.

Roman C, Platero J, Shuman J, Calame K . Ig/EBP-1: a ubiquitously expressed immunoglobulin enhancer binding protein that is similar to C/EBP and heterodimerizes with C/EBP. Genes Dev. 1990; 4(8):1404-15. DOI: 10.1101/gad.4.8.1404. View

20.

Johnson P . Molecular stop signs: regulation of cell-cycle arrest by C/EBP transcription factors. J Cell Sci. 2005; 118(Pt 12):2545-55. DOI: 10.1242/jcs.02459. View