Vitamins and : An Updated Comprehensive Meta-Analysis and Systematic Review

Overview

Journal Front Nutr

Specialty Nutritional Sciences

Date 2022 Feb 4

PMID 35118105

Authors

Xianlei Cai

Xueying Li

Yangli Jin

Miaozun Zhang

Yuan Xu

Chao Liang

Yihui Weng

Weiming Yu

Xiuyang Li

Affiliations

Soon will be listed here.

Abstract

Background: Over recent decades, epidemiological studies have shown relationships between vitamins and () infection and eradication, but the results are controversial.

Methods: A comprehensive meta-analysis and systematic review were conducted to clarify the relationships between common types of vitamins and . We applied meta-regression, subgroup analysis and sensitivity analysis to obtain available evidence. Articles published from January 1991 to June 2021 in PubMed, EMBASE, and the Cochrane Library were searched.

Results: In total, we identified 48 studies. The results indicate that -positive patients had lower serum vitamin B [standardized mean difference (SMD) = -0.30; 95% confidence interval (CI): -0.53 - -0.08], folate (SMD = -0.69; 95% CI: -1.34 - -0.04), vitamin C (SMD = -0.37; 95%CI: -0.57 - -0.18) and vitamin D (SMD = -0.34; 95% CI: -0.49 - -0.18) levels than -negative patients. Patients in which had been successfully eradicated had higher serum vitamin D levels (SMD = 1.37; 95% CI: 0.37-2.38) than in patients in which eradication had been unsuccessful. The serum vitamin B levels of -positive patients improved after successful eradication therapy (SMD = 1.85; 95% CI: 0.81-2.90), and antioxidant vitamin supplementation to an eradication regimen improved the eradication rate (risk ratio = 1.22; 95% CI: 1.02-1.44 for per-protocol analysis; risk ratio = 1.25; 95% CI: 1.06-1.47 for intention-to-treat analysis).

Conclusions: infections decrease the serum levels of several types of vitamins, eradication of could rescue its adverse effects, and antioxidant vitamin supplementation may improve the eradication rate.

Systematic Review Registration: identifier: CRD42021268127.

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