Abnormal (Hydroxy)proline Deuterium Content Redefines Hydrogen Chemical Mass

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2022 Feb 2

PMID 35107291

Authors

Hassan Gharibi

Alexey L Chernobrovkin

Gunilla Eriksson

Amir Ata Saei

Zena Timmons

Andrew C Kitchener

Daniela C Kalthoff

Kerstin Liden

Alexander A Makarov

Roman A Zubarev

Affiliations

Soon will be listed here.

Abstract

Analyzing the δH values in individual amino acids of proteins extracted from vertebrates, we unexpectedly found in some samples, notably bone collagen from seals, more than twice as much deuterium in proline and hydroxyproline residues than in seawater. This corresponds to at least 4 times higher δH than in any previously reported biogenic sample. We ruled out diet as a plausible mechanism for such anomalous enrichment. This finding puts into question the old adage that "you are what you eat".

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