Image-Guided Magnetic Thermoseed Navigation and Tumor Ablation Using a Magnetic Resonance Imaging System

Overview

Journal Adv Sci (Weinh)

Specialty Biomedical Engineering

Date 2022 Feb 2

PMID 35106965

Authors

Rebecca R Baker

Christopher Payne

Yichao Yu

Matin Mohseni

John J Connell

Fangyu Lin

Ian F Harrison

Paul Southern

Umesh S Rudrapatna

Daniel J Stuckey

Tammy L Kalber

Bernard Siow

Lewis Thorne

Shonit Punwani

Derek K Jones

Mark Emberton

Quentin A Pankhurst

Mark F Lythgoe

Affiliations

Soon will be listed here.

Abstract

Medical therapies achieve their control at expense to the patient in the form of a range of toxicities, which incur costs and diminish quality of life. Magnetic resonance navigation is an emergent technique that enables image-guided remote-control of magnetically labeled therapies and devices in the body, using a magnetic resonance imaging (MRI) system. Minimally INvasive IMage-guided Ablation (MINIMA), a novel, minimally invasive, MRI-guided ablation technique, which has the potential to avoid traditional toxicities, is presented. It comprises a thermoseed navigated to a target site using magnetic propulsion gradients generated by an MRI scanner, before inducing localized cell death using an MR-compatible thermoablative device. The authors demonstrate precise thermoseed imaging and navigation through brain tissue using an MRI system (0.3 mm), and they perform thermoablation in vitro and in vivo within subcutaneous tumors, with the focal ablation volume finely controlled by heating duration. MINIMA is a novel theranostic platform, combining imaging, navigation, and heating to deliver diagnosis and therapy in a single device.

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