In Vivo Safety Study Using Radiation at Wavelengths and Dosages Relevant to Intravascular Imaging

Overview

Journal J Biomed Opt

Specialties Biomedical Engineering
Ophthalmology

Date 2022 Feb 1

PMID 35102728

Authors

Timothy Sowers

Don Vanderlaan

Andrei Karpiouk

Daisuke Onohara

Susan Schmarkey

Serge Rousselle

Muralidhar Padala

Stanislav Emelianov

Affiliations

Soon will be listed here.

Abstract

Significance: Intravascular photoacoustic (IVPA) imaging can identify native lipid in atherosclerotic plaques in vivo. However, the large number of laser pulses required to produce 3D images is a safety concern that has not been fully addressed.

Aim: We aim to evaluate if irradiation at wavelengths and dosages relevant to IVPA imaging causes target vessel damage.

Approach: We irradiate the carotid artery of swine at one of several energy dosages using radiation at 1064 or 1720 nm and use histological evaluation by a pathologist to identify dose-dependent damage.

Results: Media necrosis was the only dose-dependent form of injury. Damage was present at a cumulative fluence of 50 J / cm2 when using 1720 nm light. Damage was more equivocally identified at 700 J / cm2 using 1064 nm.

Conclusions: In prior work, IVPA imaging of native lipid in swine has been successfully conducted below the damage thresholds identified. This indicates that it will be possible to use IVPA imaging in a clinical setting without damaging vessel tissue. Future work should determine if irradiation causes an increase in blood thrombogenicity and confirm whether damaged tissue will heal over longer time points.

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References

Jansen K, van der Steen A, Wu M, van Beusekom H, Springeling G, Li X . Spectroscopic intravascular photoacoustic imaging of lipids in atherosclerosis. J Biomed Opt. 2014; 19(2):026006. DOI: 10.1117/1.JBO.19.2.026006. View

Li Y, Lu G, Zhou Q, Chen Z . Advances in Endoscopic Photoacoustic Imaging. Photonics. 2022; 8(7). PMC: 8896876. DOI: 10.3390/photonics8070281. View

Wu M, Springeling G, Lovrak M, Mastik F, Iskander-Rizk S, Wang T . Real-time volumetric lipid imaging in vivo by intravascular photoacoustics at 20 frames per second. Biomed Opt Express. 2017; 8(2):943-953. PMC: 5330573. DOI: 10.1364/BOE.8.000943. View

Waksman R, Di Mario C, Torguson R, Ali Z, Singh V, Skinner W . Identification of patients and plaques vulnerable to future coronary events with near-infrared spectroscopy intravascular ultrasound imaging: a prospective, cohort study. Lancet. 2019; 394(10209):1629-1637. DOI: 10.1016/S0140-6736(19)31794-5. View

Wen X, Lei P, Xiong K, Zhang P, Yang S . High-robustness intravascular photoacoustic endoscope with a hermetically sealed opto-sono capsule. Opt Express. 2020; 28(13):19255-19269. DOI: 10.1364/OE.394781. View

Dana N, Sowers T, Karpiouk A, VanderLaan D, Emelianov S . Optimization of dual-wavelength intravascular photoacoustic imaging of atherosclerotic plaques using Monte Carlo optical modeling. J Biomed Opt. 2017; 22(10):1-12. PMC: 5658287. DOI: 10.1117/1.JBO.22.10.106012. View

Sowers T, Vanderlaan D, Karpiouk A, Donnelly E, Smith E, Emelianov S . Laser threshold and cell damage mechanism for intravascular photoacoustic imaging. Lasers Surg Med. 2018; 51(5):466-474. DOI: 10.1002/lsm.23026. View

Wang B, Su J, Karpiouk A, Sokolov K, Smalling R, Emelianov S . Intravascular Photoacoustic Imaging. IEEE J Quantum Electron. 2011; 16(3):588-599. PMC: 3045110. DOI: 10.1109/JSTQE.2009.2037023. View

Leng J, Zhang J, Li C, Shu C, Wang B, Lin R . Multi-spectral intravascular photoacoustic/ultrasound/optical coherence tomography tri-modality system with a fully-integrated 0.9-mm full field-of-view catheter for plaque vulnerability imaging. Biomed Opt Express. 2021; 12(4):1934-1946. PMC: 8086469. DOI: 10.1364/BOE.420724. View

10.

Wu M, Fw van der Steen A, Regar E, van Soest G . Emerging Technology Update Intravascular Photoacoustic Imaging of Vulnerable Atherosclerotic Plaque. Interv Cardiol. 2018; 11(2):120-123. PMC: 5808678. DOI: 10.15420/icr.2016:13:3. View

11.

Sethuraman S, Aglyamov S, Amirian J, Smalling R, Emelianov S . Intravascular photoacoustic imaging using an IVUS imaging catheter. IEEE Trans Ultrason Ferroelectr Freq Control. 2007; 54(5):978-86. DOI: 10.1109/tuffc.2007.343. View

12.

Keijzer M, Richards-Kortum R, Jacques S, Feld M . Fluorescence spectroscopy of turbid media: Autofluorescence of the human aorta. Appl Opt. 2010; 28(20):4286-92. DOI: 10.1364/AO.28.004286. View

13.

Hale G, Querry M . Optical Constants of Water in the 200-nm to 200-microm Wavelength Region. Appl Opt. 2010; 12(3):555-63. DOI: 10.1364/AO.12.000555. View

14.

Cao Y, Alloosh M, Sturek M, Cheng J . Highly sensitive lipid detection and localization in atherosclerotic plaque with a dual-frequency intravascular photoacoustic/ultrasound catheter. Transl Biophotonics. 2023; 2(3). PMC: 10516318. DOI: 10.1002/tbio.202000004. View

15.

Karpiouk A, Wang B, Emelianov S . Development of a catheter for combined intravascular ultrasound and photoacoustic imaging. Rev Sci Instrum. 2010; 81(1):014901. PMC: 2814830. DOI: 10.1063/1.3274197. View

16.

Jansen K, van der Steen A, van Beusekom H, Oosterhuis J, van Soest G . Intravascular photoacoustic imaging of human coronary atherosclerosis. Opt Lett. 2011; 36(5):597-9. DOI: 10.1364/OL.36.000597. View

17.

Jacques S . Optical properties of biological tissues: a review. Phys Med Biol. 2013; 58(11):R37-61. DOI: 10.1088/0031-9155/58/11/R37. View

18.

Kole A, Cao Y, Hui J, Bolad I, Alloosh M, Cheng J . Comparative Quantification of Arterial Lipid by Intravascular Photoacoustic-Ultrasound Imaging and Near-Infrared Spectroscopy-Intravascular Ultrasound. J Cardiovasc Transl Res. 2018; 12(3):211-220. PMC: 6611754. DOI: 10.1007/s12265-018-9849-2. View

19.

VanderLaan D, Karpiouk A, Yeager D, Emelianov S . Real-Time Intravascular Ultrasound and Photoacoustic Imaging. IEEE Trans Ultrason Ferroelectr Freq Control. 2017; 64(1):141-149. PMC: 5985516. DOI: 10.1109/TUFFC.2016.2640952. View

20.

Iskander-Rizk S, Wu M, Springeling G, van Beusekom H, Mastik F, Te Lintel Hekkert M . In vivo intravascular photoacoustic imaging of plaque lipid in coronary atherosclerosis. EuroIntervention. 2019; 15(5):452-456. DOI: 10.4244/EIJ-D-19-00318. View