Real-time Volumetric Lipid Imaging in Vivo by Intravascular Photoacoustics at 20 Frames Per Second

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2017 Mar 9

PMID 28270995

Citations 38

Authors

Min Wu

Geert Springeling

Matija Lovrak

Frits Mastik

Sophinese Iskander-Rizk

Tianshi Wang

Heleen M M van Beusekom

A F W van Der Steen

Gijs van Soest

Affiliations

Soon will be listed here.

Abstract

Lipid deposition can be assessed with combined intravascular photoacoustic/ultrasound (IVPA/US) imaging. To date, the clinical translation of IVPA/US imaging has been stalled by a low imaging speed and catheter complexity. In this paper, we demonstrate imaging of lipid targets in swine coronary arteries in vivo, at a clinically useful frame rate of 20 s. We confirmed image contrast for atherosclerotic plaque in human samples ex vivo. The system is on a mobile platform and provides real-time data visualization during acquisition. We achieved an IVPA signal-to-noise ratio of 20 dB. These data show that clinical translation of IVPA is possible in principle.

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References

Garg S, Serruys P, van der Ent M, Schultz C, Mastik F, van Soest G . First use in patients of a combined near infra-red spectroscopy and intra-vascular ultrasound catheter to identify composition and structure of coronary plaque. EuroIntervention. 2010; 5(6):755-6. DOI: 10.4244/eijv5i6a126. View

Jansen K, van der Steen A, Wu M, van Beusekom H, Springeling G, Li X . Spectroscopic intravascular photoacoustic imaging of lipids in atherosclerosis. J Biomed Opt. 2014; 19(2):026006. DOI: 10.1117/1.JBO.19.2.026006. View

Falk E, Shah P, Fuster V . Coronary plaque disruption. Circulation. 1995; 92(3):657-71. DOI: 10.1161/01.cir.92.3.657. View

Wang P, Rajian J, Cheng J . Spectroscopic Imaging of Deep Tissue through Photoacoustic Detection of Molecular Vibration. J Phys Chem Lett. 2013; 4(13):2177-2185. PMC: 3780401. DOI: 10.1021/jz400559a. View

Schaar J, van der Steen A, Mastik F, Baldewsing R, Serruys P . Intravascular palpography for vulnerable plaque assessment. J Am Coll Cardiol. 2006; 47(8 Suppl):C86-91. DOI: 10.1016/j.jacc.2006.01.035. View

Cao Y, Hui J, Kole A, Wang P, Yu Q, Chen W . High-sensitivity intravascular photoacoustic imaging of lipid-laden plaque with a collinear catheter design. Sci Rep. 2016; 6:25236. PMC: 4848524. DOI: 10.1038/srep25236. View

Horton N, Wang K, Kobat D, Clark C, Wise F, Schaffer C . three-photon microscopy of subcortical structures within an intact mouse brain. Nat Photonics. 2013; 7(3). PMC: 3864872. DOI: 10.1038/nphoton.2012.336. View

Wang B, Su J, Amirian J, Litovsky S, Smalling R, Emelianov S . Detection of lipid in atherosclerotic vessels using ultrasound-guided spectroscopic intravascular photoacoustic imaging. Opt Express. 2010; 18(5):4889-97. PMC: 3378348. DOI: 10.1364/OE.18.004889. View

Leung K, Baldewsing R, Mastik F, Schaar J, Gisolf A, van der Steen A . Motion compensation for intravascular ultrasound palpography. IEEE Trans Ultrason Ferroelectr Freq Control. 2006; 53(7):1269-80. DOI: 10.1109/tuffc.2006.1665075. View

10.

Wu M, Fw van der Steen A, Regar E, van Soest G . Emerging Technology Update Intravascular Photoacoustic Imaging of Vulnerable Atherosclerotic Plaque. Interv Cardiol. 2018; 11(2):120-123. PMC: 5808678. DOI: 10.15420/icr.2016:13:3. View

11.

Li Y, Gong X, Liu C, Lin R, Hau W, Bai X . High-speed intravascular spectroscopic photoacoustic imaging at 1000 A-lines per second with a 0.9-mm diameter catheter. J Biomed Opt. 2015; 20(6):065006. DOI: 10.1117/1.JBO.20.6.065006. View

12.

Manfrini O, Mont E, Leone O, Arbustini E, Eusebi V, Virmani R . Sources of error and interpretation of plaque morphology by optical coherence tomography. Am J Cardiol. 2006; 98(2):156-9. DOI: 10.1016/j.amjcard.2006.01.097. View

13.

Schaar J, Muller J, Falk E, Virmani R, Fuster V, Serruys P . Terminology for high-risk and vulnerable coronary artery plaques. Report of a meeting on the vulnerable plaque, June 17 and 18, 2003, Santorini, Greece. Eur Heart J. 2004; 25(12):1077-82. DOI: 10.1016/j.ehj.2004.01.002. View

14.

Wu M, Jansen K, van der Steen A, van Soest G . Specific imaging of atherosclerotic plaque lipids with two-wavelength intravascular photoacoustics. Biomed Opt Express. 2015; 6(9):3276-86. PMC: 4574656. DOI: 10.1364/BOE.6.003276. View

15.

Jansen K, Wu M, van der Steen A, van Soest G . Photoacoustic imaging of human coronary atherosclerosis in two spectral bands. Photoacoustics. 2014; 2(1):12-20. PMC: 4182816. DOI: 10.1016/j.pacs.2013.11.003. View

16.

Yang J, Maslov K, Yang H, Zhou Q, Shung K, Wang L . Photoacoustic endoscopy. Opt Lett. 2009; 34(10):1591-3. PMC: 2738934. DOI: 10.1364/ol.34.001591. View

17.

Wang B, Karpiouk A, Yeager D, Amirian J, Litovsky S, Smalling R . In vivo intravascular ultrasound-guided photoacoustic imaging of lipid in plaques using an animal model of atherosclerosis. Ultrasound Med Biol. 2012; 38(12):2098-103. PMC: 3511618. DOI: 10.1016/j.ultrasmedbio.2012.08.006. View

18.

Jansen K, Wu M, van der Steen A, van Soest G . Lipid detection in atherosclerotic human coronaries by spectroscopic intravascular photoacoustic imaging. Opt Express. 2013; 21(18):21472-84. DOI: 10.1364/OE.21.021472. View

19.

Tearney G, Regar E, Akasaka T, Adriaenssens T, Barlis P, Bezerra H . Consensus standards for acquisition, measurement, and reporting of intravascular optical coherence tomography studies: a report from the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation. J Am Coll Cardiol. 2012; 59(12):1058-72. DOI: 10.1016/j.jacc.2011.09.079. View

20.

Bourantas C, Jaffer F, Gijsen F, van Soest G, Madden S, Courtney B . Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology. Eur Heart J. 2016; 38(6):400-412. PMC: 5837589. DOI: 10.1093/eurheartj/ehw097. View