Standalone Portable Xenon-129 Hyperpolariser for Multicentre Clinical Magnetic Resonance Imaging of the Lungs

Overview

Journal Br J Radiol

Publisher Oxford University Press

Specialty Radiology

Date 2022 Jan 31

PMID 35100003

Authors

Graham Norquay

Guilhem J Collier

Oliver I Rodgers

Andrew B Gill

Nicholas J Screaton

Jim Wild

Affiliations

Soon will be listed here.

Abstract

Objectives: Design and build a portable xenon-129 (Xe) hyperpolariser for clinically accessible Xe lung MRI.

Methods: The polariser system consists of six main functional components: (i) a laser diode array and optics; (ii) a B coil assembly; (iii) an oven containing an optical cell; (iv) NMR and optical spectrometers; (v) a gas-handling manifold; and (vi) a cryostat within a permanent magnet. All components run without external utilities such as compressed air or three-phase electricity, and require just three mains sockets for operation. The system can be manually transported in a lightweight van and rapidly installed on a small estates footprint in a hospital setting.

Results: The polariser routinely provides polarised Xe for routine clinical lung MRI. To test the concept of portability and rapid deployment, it was transported 200 km, installed at a hospital with no previous experience with the technology and Xe MR images of a diagnostic quality were acquired the day after system transport and installation.

Conclusion: This portable Xe hyperpolariser system could form the basis of a cost-effective platform for wider clinical dissemination and multicentre evaluation of Xe lung MR imaging.

Advances In Knowledge: Our work successfully demonstrates the feasibility of multicentre clinical Xe MRI with a portable hyperpolariser system.

Citing Articles

Diffusion weighted hyperpolarized Xe MRI of the lung with 2D and 3D (FLORET) spiral.

Bdaiwi A, Willmering M, Wang H, Cleveland Z Magn Reson Med. 2022; 89(4):1342-1356.

PMID: 36352793 PMC: 9892235. DOI: 10.1002/mrm.29518.

functional imaging of the lung special feature: introductory editorial.

Grenier P, Hoffman E, Screaton N, Seo J Br J Radiol. 2022; 95(1132):20229004.

PMID: 35312377 PMC: 9153701. DOI: 10.1259/bjr.20229004.

References

Chauvin C, Liagre L, Boutin C, Mari E, Leonce E, Carret G . Note: Spin-exchange optical pumping in a van. Rev Sci Instrum. 2016; 87(1):016105. DOI: 10.1063/1.4940928. View

Nikolaou P, Coffey A, Walkup L, Gust B, Whiting N, Newton H . Near-unity nuclear polarization with an open-source 129Xe hyperpolarizer for NMR and MRI. Proc Natl Acad Sci U S A. 2013; 110(35):14150-5. PMC: 3761567. DOI: 10.1073/pnas.1306586110. View

Niedbalski P, Hall C, Castro M, Eddy R, Rayment J, Svenningsen S . Protocols for multi-site trials using hyperpolarized Xe MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the Xe MRI clinical trials consortium. Magn Reson Med. 2021; 86(6):2966-2986. DOI: 10.1002/mrm.28985. View

Norquay G, Collier G, Rao M, Stewart N, Wild J . ^{129}Xe-Rb Spin-Exchange Optical Pumping with High Photon Efficiency. Phys Rev Lett. 2018; 121(15):153201. DOI: 10.1103/PhysRevLett.121.153201. View

Shepelytskyi Y, Hane F, Grynko V, Li T, Hassan A, Albert M . Hyperpolarized Xe Time-of-Flight MR Imaging of Perfusion and Brain Function. Diagnostics (Basel). 2020; 10(9). PMC: 7554935. DOI: 10.3390/diagnostics10090630. View

Chacon-Caldera J, Maunder A, Rao M, Norquay G, Rodgers O, Clemence M . Dissolved hyperpolarized xenon-129 MRI in human kidneys. Magn Reson Med. 2019; 83(1):262-270. PMC: 6852523. DOI: 10.1002/mrm.27923. View

He M, Robertson S, Kaushik S, Freeman M, Virgincar R, Davies J . Dose and pulse sequence considerations for hyperpolarized (129)Xe ventilation MRI. Magn Reson Imaging. 2015; 33(7):877-85. PMC: 4466055. DOI: 10.1016/j.mri.2015.04.005. View

Rao M, Stewart N, Griffiths P, Norquay G, Wild J . Imaging Human Brain Perfusion with Inhaled Hyperpolarized Xe MR Imaging. Radiology. 2017; 286(2):659-665. DOI: 10.1148/radiol.2017162881. View

Birchall J, Nikolaou P, Coffey A, Kidd B, Murphy M, Molway M . Batch-Mode Clinical-Scale Optical Hyperpolarization of Xenon-129 Using an Aluminum Jacket with Rapid Temperature Ramping. Anal Chem. 2020; 92(6):4309-4316. DOI: 10.1021/acs.analchem.9b05051. View

10.

Rao M, Norquay G, Stewart N, Wild J . Measuring Xe transfer across the blood-brain barrier using MR spectroscopy. Magn Reson Med. 2021; 85(6):2939-2949. PMC: 7986241. DOI: 10.1002/mrm.28646. View

11.

Korchak S, Kilian W, Mitschang L . Configuration and Performance of a Mobile (129)Xe Polarizer. Appl Magn Reson. 2013; 44(1-2):65-80. PMC: 3549238. DOI: 10.1007/s00723-012-0425-7. View

12.

Stewart N, Smith L, Chan H, Eaden J, Rajaram S, Swift A . Lung MRI with hyperpolarised gases: current & future clinical perspectives. Br J Radiol. 2021; 95(1132):20210207. PMC: 9153706. DOI: 10.1259/bjr.20210207. View

13.

Ebert M, Grossmann T, Heil W, Otten W, Surkau R, Leduc M . Nuclear magnetic resonance imaging with hyperpolarised helium-3. Lancet. 1996; 347(9011):1297-9. DOI: 10.1016/s0140-6736(96)90940-x. View

14.

Hersman F, Ruset I, Ketel S, Muradian I, Covrig S, Distelbrink J . Large production system for hyperpolarized 129Xe for human lung imaging studies. Acad Radiol. 2008; 15(6):683-92. PMC: 2475596. DOI: 10.1016/j.acra.2007.09.020. View