Hyperpolarized Xe Time-of-Flight MR Imaging of Perfusion and Brain Function

Overview

Journal Diagnostics (Basel)

Specialty Radiology

Date 2020 Aug 29

PMID 32854196

Citations 11

Authors

Yurii Shepelytskyi

Francis T Hane

Vira Grynko

Tao Li

Ayman Hassan

Mitchell S Albert

Affiliations

Soon will be listed here.

Abstract

Perfusion measurements can provide vital information about the homeostasis of an organ and can therefore be used as biomarkers to diagnose a variety of cardiovascular, renal, and neurological diseases. Currently, the most common techniques to measure perfusion are O positron emission tomography (PET), xenon-enhanced computed tomography (CT), single photon emission computed tomography (SPECT), dynamic contrast enhanced (DCE) MRI, and arterial spin labeling (ASL) MRI. Here, we show how regional perfusion can be quantitively measured with magnetic resonance imaging (MRI) using time-resolved depolarization of hyperpolarized (HP) xenon-129 (Xe), and the application of this approach to detect changes in cerebral blood flow (CBF) due to a hemodynamic response in response to brain stimuli. The investigated HP Xe Time-of-Flight (TOF) technique produced perfusion images with an average signal-to-noise ratio (SNR) of 10.35. Furthermore, to our knowledge, the first hemodynamic response (HDR) map was acquired in healthy volunteers using the HP Xe TOF imaging. Responses to visual and motor stimuli were observed. The acquired HP TOF HDR maps correlated well with traditional proton blood oxygenation level-dependent functional MRI. Overall, this study expands the field of HP MRI with a novel dynamic imaging technique suitable for rapid and quantitative perfusion imaging.

Citing Articles

Developing Hyperpolarized Butane Gas for Ventilation Lung Imaging.

Ariyasingha N, Samoilenko A, Chowdhury M, Nantogma S, Oladun C, Birchall J Chem Biomed Imaging. 2024; 2(10):698-710.

PMID: 39483636 PMC: 11523004. DOI: 10.1021/cbmi.4c00041.

Xe Dynamic Nuclear Polarization Demystified: The Influence of the Glassing Matrix on the Radical Properties.

Wistrom E, Hyacinthe J, Le T, Gruetter R, Capozzi A J Phys Chem Lett. 2024; 15(11):2957-2965.

PMID: 38453156 PMC: 10961830. DOI: 10.1021/acs.jpclett.4c00177.

Hyperpolarized Xenon-129 Chemical Exchange Saturation Transfer (HyperCEST) Molecular Imaging: Achievements and Future Challenges.

Batarchuk V, Shepelytskyi Y, Grynko V, Kovacs A, Hodgson A, Rodriguez K Int J Mol Sci. 2024; 25(3).

PMID: 38339217 PMC: 10856220. DOI: 10.3390/ijms25031939.

Revealing a Third Dissolved-Phase Xenon-129 Resonance in Blood Caused by Hemoglobin Glycation.

Mikowska L, Grynko V, Shepelytskyi Y, Ruset I, Deschamps J, Aalto H Int J Mol Sci. 2023; 24(14).

PMID: 37511071 PMC: 10380088. DOI: 10.3390/ijms241411311.

Feasibility of flow-related enhancement brain perfusion MRI.

Glandorf J, Klimes F, Voskrebenzev A, Gutberlet M, Kern A, Kornemann N PLoS One. 2022; 17(11):e0276912.

PMID: 36395180 PMC: 9671356. DOI: 10.1371/journal.pone.0276912.

References

Gillis K, McComb C, Patel R, Stevens K, Schneider M, Radjenovic A . Non-Contrast Renal Magnetic Resonance Imaging to Assess Perfusion and Corticomedullary Differentiation in Health and Chronic Kidney Disease. Nephron. 2016; 133(3):183-92. DOI: 10.1159/000447601. View

Fox M, Ouriadov A, Thind K, Hegarty E, Wong E, Hope A . Detection of radiation induced lung injury in rats using dynamic hyperpolarized (129)Xe magnetic resonance spectroscopy. Med Phys. 2014; 41(7):072302. DOI: 10.1118/1.4881523. View

Neale C, Johnston P, Hughes M, Scholey A . Functional Activation during the Rapid Visual Information Processing Task in a Middle Aged Cohort: An fMRI Study. PLoS One. 2015; 10(10):e0138994. PMC: 4619344. DOI: 10.1371/journal.pone.0138994. View

Perazella M . Nephrogenic systemic fibrosis, kidney disease, and gadolinium: is there a link?. Clin J Am Soc Nephrol. 2007; 2(2):200-2. DOI: 10.2215/CJN.00030107. View

Turesky T, Olulade O, Luetje M, Eden G . An fMRI study of finger tapping in children and adults. Hum Brain Mapp. 2018; 39(8):3203-3215. PMC: 6052794. DOI: 10.1002/hbm.24070. View

Zhou X, Mazzanti M, Chen J, Tzeng Y, Mansour J, Gereige J . Reinvestigating hyperpolarized (129)Xe longitudinal relaxation time in the rat brain with noise considerations. NMR Biomed. 2007; 21(3):217-25. DOI: 10.1002/nbm.1184. View

Greenberg D, Jin K . From angiogenesis to neuropathology. Nature. 2005; 438(7070):954-9. DOI: 10.1038/nature04481. View

Luttropp H, Thomasson R, Dahm S, Persson J, Werner O . Clinical experience with minimal flow xenon anesthesia. Acta Anaesthesiol Scand. 1994; 38(2):121-5. DOI: 10.1111/j.1399-6576.1994.tb03852.x. View

Hashido T, Saito S, Ishida T . A radiomics-based comparative study on arterial spin labeling and dynamic susceptibility contrast perfusion-weighted imaging in gliomas. Sci Rep. 2020; 10(1):6121. PMC: 7145821. DOI: 10.1038/s41598-020-62658-9. View

10.

Kruger S, Nagle S, Couch M, Ohno Y, Albert M, Fain S . Functional imaging of the lungs with gas agents. J Magn Reson Imaging. 2015; 43(2):295-315. PMC: 4733870. DOI: 10.1002/jmri.25002. View

11.

Ni L, Li J, Li W, Zhou F, Wang F, Schwarz C . The value of resting-state functional MRI in subacute ischemic stroke: comparison with dynamic susceptibility contrast-enhanced perfusion MRI. Sci Rep. 2017; 7:41586. PMC: 5282488. DOI: 10.1038/srep41586. View

12.

Okazawa H, Higashino Y, Tsujikawa T, Arishima H, Mori T, Kiyono Y . Noninvasive method for measurement of cerebral blood flow using O-15 water PET/MRI with ASL correlation. Eur J Radiol. 2018; 105:102-109. DOI: 10.1016/j.ejrad.2018.05.033. View

13.

Petersen E, Zimine I, Ho Y, Golay X . Non-invasive measurement of perfusion: a critical review of arterial spin labelling techniques. Br J Radiol. 2006; 79(944):688-701. DOI: 10.1259/bjr/67705974. View

14.

Hu W, Wang Z, Lee V, Trojanowski J, Detre J, Grossman M . Distinct cerebral perfusion patterns in FTLD and AD. Neurology. 2010; 75(10):881-8. PMC: 2938974. DOI: 10.1212/WNL.0b013e3181f11e35. View

15.

Zhao L, Fielden S, Feng X, Wintermark M, Mugler 3rd J, Meyer C . Rapid 3D dynamic arterial spin labeling with a sparse model-based image reconstruction. Neuroimage. 2015; 121:205-16. PMC: 4615585. DOI: 10.1016/j.neuroimage.2015.07.018. View

16.

Vidorreta M, Wang Z, Chang Y, Wolk D, Fernandez-Seara M, Detre J . Whole-brain background-suppressed pCASL MRI with 1D-accelerated 3D RARE Stack-Of-Spirals readout. PLoS One. 2017; 12(8):e0183762. PMC: 5570334. DOI: 10.1371/journal.pone.0183762. View

17.

Ito H, Inoue K, Goto R, Kinomura S, Taki Y, Okada K . Database of normal human cerebral blood flow measured by SPECT: I. Comparison between I-123-IMP, Tc-99m-HMPAO, and Tc-99m-ECD as referred with O-15 labeled water PET and voxel-based morphometry. Ann Nucl Med. 2006; 20(2):131-8. DOI: 10.1007/BF02985625. View

18.

Liu X, Madhankumar A, Miller P, Duck K, Hafenstein S, Rizk E . MRI contrast agent for targeting glioma: interleukin-13 labeled liposome encapsulating gadolinium-DTPA. Neuro Oncol. 2015; 18(5):691-9. PMC: 4827043. DOI: 10.1093/neuonc/nov263. View

19.

Ruset I, Ketel S, Hersman F . Optical pumping system design for large production of hyperpolarized. Phys Rev Lett. 2006; 96(5):053002. DOI: 10.1103/PhysRevLett.96.053002. View

20.

Gountouna V, Job D, McIntosh A, Moorhead T, Lymer G, Whalley H . Functional Magnetic Resonance Imaging (fMRI) reproducibility and variance components across visits and scanning sites with a finger tapping task. Neuroimage. 2009; 49(1):552-60. DOI: 10.1016/j.neuroimage.2009.07.026. View