Fate-mapping Mice: New Tools and Technology for Immune Discovery

Overview

Journal Trends Immunol

Specialty Allergy & Immunology

Date 2022 Jan 31

PMID 35094945

Authors

Scarlett E Lee

Brian D Rudd

Norah L Smith

Affiliations

Soon will be listed here.

Abstract

The fate-mapping mouse has become an essential tool in the immunologist's toolbox. Although traditionally used by developmental biologists to trace the origins of cells, immunologists are turning to fate-mapping to better understand the development and function of immune cells. Thus, an expansion in the variety of fate-mapping mouse models has occurred to answer fundamental questions about the immune system. These models are also being combined with new genetic tools to study cancer, infection, and autoimmunity. In this review, we summarize different types of fate-mapping mice and describe emerging technologies that might allow immunologists to leverage this valuable tool and expand our functional knowledge of the immune system.

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