Liquid Biopsy in Lung Cancer: Significance in Diagnostics, Prediction, and Treatment Monitoring

Overview

Journal Mol Cancer

Publisher Biomed Central

Specialties Molecular Biology
Oncology

Date 2022 Jan 21

PMID 35057806

Authors

Wen Li

Ji-Bin Liu

Li-Kun Hou

Fei Yu

Jie Zhang

Wei Wu

Xiao-Mei Tang

Feng Sun

Hai-Min Lu

Jing Deng

Jie Bai

Juan Li

Chun-Yan Wu

Qin-Lu Lin

Zhong-Wei Lv

Gao-Ren Wang

Geng-Xi Jiang

Yu-Shui Ma

Da Fu

Affiliations

Soon will be listed here.

Abstract

Primary lung cancer is one of the most common malignant tumors in China. Approximately 60% of lung cancer patients have distant metastasis at the initial diagnosis, so it is necessary to find new tumor markers for early diagnosis and individualized treatment. Tumor markers contribute to the early diagnosis of lung cancer and play important roles in early detection and treatment, as well as in precision medicine, efficacy monitoring, and prognosis prediction. The pathological diagnosis of lung cancer in small biopsy specimens determines whether there are tumor cells in the biopsy and tumor type. Because biopsy is traumatic and the compliance of patients with multiple biopsies is poor, liquid biopsy has become a hot research direction. Liquid biopsies are advantageous because they are nontraumatic, easy to obtain, reflect the overall state of the tumor, and allow for real-time monitoring. At present, liquid biopsies mainly include circulating tumor cells, circulating tumor DNA, exosomes, microRNA, circulating RNA, tumor platelets, and tumor endothelial cells. This review introduces the research progress and clinical application prospect of liquid biopsy technology for lung cancer.

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