The Application of Beta-Tricalcium Phosphate in Implant Dentistry: A Systematic Evaluation of Clinical Studies

Overview

Journal Materials (Basel)

Publisher MDPI

Date 2022 Jan 21

PMID 35057372

Authors

Elisabet Roca-Millan

Enric Jane-Salas

Antonio Mari-Roig

Alvaro Jimenez-Guerra

Ivan Ortiz-Garcia

Eugenio Velasco-Ortega

Jose Lopez-Lopez

Loreto Monsalve-Guil

Affiliations

Soon will be listed here.

Abstract

The demand for synthetic graft materials in implant dentistry is rising. This systematic review aims to evaluate the survival rate of dental implants placed simultaneously with bone regeneration procedures using the material β-tricalcium phosphate, one of the most promising synthetic graft materials. The electronic search was conducted in PubMed, Scielo, and the Cochrane Central Register of Controlled Trials. Five randomized clinical trials, one non-randomized controlled clinical trial and four observational studies without control group were include. Implant survival rate and other clinical, radiographic, and histological parameters did not differ from those of implants placed simultaneously with another type of graft material, or placed in blood clots or natural alveolar ridges. Based on the available literature, β-tricalcium phosphate seems to be a promising graft material in implant dentistry. Nevertheless, more randomized clinical trials, with long follow-up periods, preoperative and postoperative CBCT, and histological analysis, are necessary to assess its long-term behavior.

Citing Articles

A preliminary study of cell-based bone tissue engineering into 3D-printed β-tricalcium phosphate scaffolds and polydioxanone membranes.

Pitol-Palin L, Moura J, Frigerio P, de Souza Batista F, Saska S, Oliveira L Sci Rep. 2024; 14(1):31184.

PMID: 39732806 PMC: 11682175. DOI: 10.1038/s41598-024-82334-6.

Determining Hydroxyapatite Filling Volume for the Treatment of Post-Extraction Alveoli Based on Measurements of Alveolar Volume in Relation to the Body Weight of Dogs.

Misztal-Kunecka A, Przadka P, Jez M, Dzimira S Vet Sci. 2024; 11(12).

PMID: 39728973 PMC: 11680159. DOI: 10.3390/vetsci11120633.

Advances in Bioceramics for Bone Regeneration: A Narrative Review.

Brochu B, Sturm S, Kawase De Queiroz Goncalves J, Mirsky N, Sandino A, Panthaki K Biomimetics (Basel). 2024; 9(11).

PMID: 39590262 PMC: 11592113. DOI: 10.3390/biomimetics9110690.

Pre-vascularized porous gelatin-coated β-tricalcium phosphate scaffolds for bone regeneration: an in vivo and in vitro investigation.

Nokhbatolfoghahaei H, Baniameri S, Tabrizi R, Yousefi-Koma A, Dehghan M, Derakhshan S In Vitro Cell Dev Biol Anim. 2024; 61(1):67-80.

PMID: 39382735 DOI: 10.1007/s11626-024-00973-5.

Radiographic Study of Transcrestal Sinus Floor Elevation Using Osseodensification Technique with Graft Material: A Pilot Study.

Sulyhan-Sulyhan K, Barbera-Millan J, Larrazabal-Moron C, Espinosa-Gimenez J, Gomez-Adrian M Biomimetics (Basel). 2024; 9(5).

PMID: 38786485 PMC: 11118885. DOI: 10.3390/biomimetics9050276.

References

Bettach R, Guillaume B, Taschieri S, Fabbro M . Clinical performance of a highly porous beta-TCP as the grafting material for maxillary sinus augmentation. Implant Dent. 2014; 23(3):357-64. DOI: 10.1097/ID.0000000000000102. View

Elani H, Starr J, Da Silva J, Gallucci G . Trends in Dental Implant Use in the U.S., 1999-2016, and Projections to 2026. J Dent Res. 2018; 97(13):1424-1430. PMC: 6854267. DOI: 10.1177/0022034518792567. View

Slim K, Nini E, Forestier D, Kwiatkowski F, Panis Y, Chipponi J . Methodological index for non-randomized studies (minors): development and validation of a new instrument. ANZ J Surg. 2003; 73(9):712-6. DOI: 10.1046/j.1445-2197.2003.02748.x. View

Sheikh Z, Hamdan N, Ikeda Y, Grynpas M, Ganss B, Glogauer M . Natural graft tissues and synthetic biomaterials for periodontal and alveolar bone reconstructive applications: a review. Biomater Res. 2017; 21:9. PMC: 5460509. DOI: 10.1186/s40824-017-0095-5. View

Zijderveld S, Schulten E, Aartman I, Ten Bruggenkate C . Long-term changes in graft height after maxillary sinus floor elevation with different grafting materials: radiographic evaluation with a minimum follow-up of 4.5 years. Clin Oral Implants Res. 2009; 20(7):691-700. DOI: 10.1111/j.1600-0501.2008.01697.x. View

Bohner M, Le Gars Santoni B, Dobelin N . β-tricalcium phosphate for bone substitution: Synthesis and properties. Acta Biomater. 2020; 113:23-41. DOI: 10.1016/j.actbio.2020.06.022. View

Ormianer Z, Palti A, Shifman A . Survival of immediately loaded dental implants in deficient alveolar bone sites augmented with beta-tricalcium phosphate. Implant Dent. 2006; 15(4):395-403. DOI: 10.1097/01.id.0000239316.82325.8c. View

Cheah C, Al-Namnam N, Lau M, Lim G, Raman R, Fairbairn P . Synthetic Material for Bone, Periodontal, and Dental Tissue Regeneration: Where Are We Now, and Where Are We Heading Next?. Materials (Basel). 2021; 14(20). PMC: 8537464. DOI: 10.3390/ma14206123. View

Ebrahimi M, Botelho M, Dorozhkin S . Biphasic calcium phosphates bioceramics (HA/TCP): Concept, physicochemical properties and the impact of standardization of study protocols in biomaterials research. Mater Sci Eng C Mater Biol Appl. 2016; 71:1293-1312. DOI: 10.1016/j.msec.2016.11.039. View

10.

Ozyuvaci H, Bilgic B, Firatli E . Radiologic and histomorphometric evaluation of maxillary sinus grafting with alloplastic graft materials. J Periodontol. 2003; 74(6):909-15. DOI: 10.1902/jop.2003.74.6.909. View

11.

Haugen H, Lyngstadaas S, Rossi F, Perale G . Bone grafts: which is the ideal biomaterial?. J Clin Periodontol. 2019; 46 Suppl 21:92-102. DOI: 10.1111/jcpe.13058. View

12.

Suba Z, Takacs D, Matusovits D, Barabas J, Fazekas A, Szabo G . Maxillary sinus floor grafting with beta-tricalcium phosphate in humans: density and microarchitecture of the newly formed bone. Clin Oral Implants Res. 2006; 17(1):102-8. DOI: 10.1111/j.1600-0501.2005.01166.x. View

13.

Sheikh Z, Najeeb S, Khurshid Z, Verma V, Rashid H, Glogauer M . Biodegradable Materials for Bone Repair and Tissue Engineering Applications. Materials (Basel). 2017; 8(9):5744-5794. PMC: 5512653. DOI: 10.3390/ma8095273. View

14.

Moher D, Liberati A, Tetzlaff J, Altman D . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009; 6(7):e1000097. PMC: 2707599. DOI: 10.1371/journal.pmed.1000097. View

15.

Merli M, Moscatelli M, Mariotti G, Pagliaro U, Raffaelli E, Nieri M . Comparing membranes and bone substitutes in a one-stage procedure for horizontal bone augmentation. Three-year post-loading results of a double-blind randomised controlled trial. Eur J Oral Implantol. 2018; 11(4):441-452. View

16.

Trombelli L, Franceschetti G, Stacchi C, Minenna L, Riccardi O, Di Raimondo R . Minimally invasive transcrestal sinus floor elevation with deproteinized bovine bone or β-tricalcium phosphate: a multicenter, double-blind, randomized, controlled clinical trial. J Clin Periodontol. 2013; 41(3):311-9. DOI: 10.1111/jcpe.12210. View

17.

Yamada M, Egusa H . Current bone substitutes for implant dentistry. J Prosthodont Res. 2017; 62(2):152-161. DOI: 10.1016/j.jpor.2017.08.010. View

18.

Merli M, Moscatelli M, Mariotti G, Pagliaro U, Breschi L, Mazzoni A . Membranes and Bone Substitutes in a One-Stage Procedure for Horizontal Bone Augmentation: A Histologic Double-Blind Parallel Randomized Controlled Trial. Int J Periodontics Restorative Dent. 2015; 35(4):463-71. DOI: 10.11607/prd.2418. View

19.

Szabo G, Huys L, Coulthard P, Maiorana C, Garagiola U, Barabas J . A prospective multicenter randomized clinical trial of autogenous bone versus beta-tricalcium phosphate graft alone for bilateral sinus elevation: histologic and histomorphometric evaluation. Int J Oral Maxillofac Implants. 2005; 20(3):371-81. View

20.

Okada T, Kanai T, Tachikawa N, Munakata M, Kasugai S . Histological and Histomorphometrical Determination of the Biogradation of β-Tricalcium Phosphate Granules in Maxillary Sinus Floor Augmentation: A Prospective Observational Study. Implant Dent. 2017; 26(2):275-283. DOI: 10.1097/ID.0000000000000577. View