Application of Platform for the Development and Optimization of Fully Bioresorbable Vascular Scaffold Designs

Overview

Journal Front Med Technol

Specialty Biomedical Engineering

Date 2022 Jan 20

PMID 35047953

Authors

Miljan Milosevic

Milos Anic

Dalibor Nikolic

Vladimir Geroski

Bogdan Milicevic

Milos Kojic

Nenad Filipovic

Affiliations

Soon will be listed here.

Abstract

Bioresorbable vascular scaffolds (BVS), made either from polymers or from metals, are promising materials for treating coronary artery disease through the processes of percutaneous transluminal coronary angioplasty. Despite the opinion that bioresorbable polymers are more promising for coronary stents, their long-term advantages over metallic alloys have not yet been demonstrated. The development of new polymer-based BVS or optimization of the existing ones requires engineers to perform many very expensive mechanical tests to identify optimal structural geometry and material characteristics. mechanical testing opens the possibility for a fast and low-cost process of analysis of all the mechanical characteristics and also provides the possibility to compare two or more competing designs. In this study, we used a recently introduced material model of poly-l-lactic acid (PLLA) fully bioresorbable vascular scaffold and recently empowered numerical InSilc platform to perform mechanicals tests of two different stent designs with different material and geometrical characteristics. The result of inflation, radial compression, three-point bending, and two-plate crush tests shows that numerical procedures with true experimental constitutive relationships could provide reliable conclusions and a significant contribution to the optimization and design of bioresorbable polymer-based stents.

Citing Articles

Thermo-Mechanical Characterization of 4D-Printed Biodegradable Shape-Memory Scaffolds Using Four-Axis 3D-Printing System.

Slavkovic V, Palic N, Milenkovic S, Zivic F, Grujovic N Materials (Basel). 2023; 16(14).

PMID: 37512458 PMC: 10386114. DOI: 10.3390/ma16145186.

InSilc Computational Tool for Optimization of Drug-Eluting Bioresorbable Vascular Scaffolds.

Milosevic M, Anic M, Nikolic D, Milicevic B, Kojic M, Filipovic N Comput Math Methods Med. 2022; 2022:5311208.

PMID: 36105243 PMC: 9467806. DOI: 10.1155/2022/5311208.

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