1,2-Naphthoquinone-4-sulfonic Acid Salts in Organic Synthesis

Overview

Journal Beilstein J Org Chem

Specialty Chemistry

Date 2022 Jan 20

PMID 35047082

Authors

Ruan Carlos B Ribeiro

Patricia G Ferreira

Amanda de A Borges

Luana da S M Forezi

Fernando de Carvalho da Silva

Vitor F Ferreira

Affiliations

Soon will be listed here.

Abstract

Several low molecular weight naphthoquinones are very useful in organic synthesis. These compounds have given rise to thousands of other naphthoquinones that have been tested against various microorganisms and pharmacological targets, including being used in the preparation of several drugs that are on the pharmaceutical market. Among these naphthoquinones, the series of compounds prepared from 1,2-naphthoquinone-4-sulfonic acid salts (β-NQS) stands out. In addition to being used in organic synthesis, they are excellent analytical derivatization reagents to spectrophotometrically determine drugs containing primary and secondary amino groups. This review summarizes the literature involving β-NQS.

Citing Articles

Studies of the Functionalized α-Hydroxy--Quinone Imine Derivatives Stabilized by Intramolecular Hydrogen Bond.

Gaile A, Belyakov S, Durena R, Griscenko N, Zukuls A, Batenko N Molecules. 2024; 29(7).

PMID: 38611892 PMC: 11013408. DOI: 10.3390/molecules29071613.

Exploring the Antimicrobial and Antitumoral Activities of Naphthoquinone-Grafted Chitosans.

Petzold Pauli F, Freitas C, Pereira P, Magalhaes A, de Carvalho da Silva F, Paschoalin V Polymers (Basel). 2023; 15(6).

PMID: 36987212 PMC: 10053705. DOI: 10.3390/polym15061430.

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