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Finding and Characterizing Repeats in Plant Genomes

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Specialty Molecular Biology
Date 2022 Jan 17
PMID 35037215
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Abstract

Plant genomes contain a particularly high proportion of repeated structures of various types. This chapter proposes a guided tour of the available software that can help biologists to scan automatically for these repeats in sequence data or check hypothetical models intended to characterize their structures. Since transposable elements (TEs) are a major source of repeats in plants, many methods have been used or developed for this broad class of sequences. They are representative of the range of tools available for other classes of repeats and we have provided two sections on this topic (for the analysis of genomes or directly of sequenced reads), as well as a selection of the main existing software. It may be hard to keep up with the profusion of proposals in this dynamic field and the rest of the chapter is devoted to the foundations of an efficient search for repeats and more complex patterns. We first introduce the key concepts of the art of indexing and mapping or querying sequences. We end the chapter with the more prospective issue of building models of repeat families. We present the Machine Learning approach first, seeking to build predictors automatically for some families of ET, from a set of sequences known to belong to this family. A second approach, the linguistic (or syntactic) approach, allows biologists to describe themselves and check the validity of models of their favorite repeat family.

Citing Articles

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References
1.
Barghini E, Natali L, Cossu R, Giordani T, Pindo M, Cattonaro F . The peculiar landscape of repetitive sequences in the olive (Olea europaea L.) genome. Genome Biol Evol. 2014; 6(4):776-91. PMC: 4007544. DOI: 10.1093/gbe/evu058. View

2.
Lim K, Keong Kwoh C, Hsu L, Wirawan A . Review of tandem repeat search tools: a systematic approach to evaluating algorithmic performance. Brief Bioinform. 2012; 14(1):67-81. DOI: 10.1093/bib/bbs023. View

3.
Harris R, Cechova M, Makova K . Noise-cancelling repeat finder: uncovering tandem repeats in error-prone long-read sequencing data. Bioinformatics. 2019; 35(22):4809-4811. PMC: 6853708. DOI: 10.1093/bioinformatics/btz484. View

4.
Warburton P, Giordano J, Cheung F, Gelfand Y, Benson G . Inverted repeat structure of the human genome: the X-chromosome contains a preponderance of large, highly homologous inverted repeats that contain testes genes. Genome Res. 2004; 14(10A):1861-9. PMC: 524409. DOI: 10.1101/gr.2542904. View

5.
Shortt J, Ruggiero R, Cox C, Wacholder A, Pollock D . Finding and extending ancient simple sequence repeat-derived regions in the human genome. Mob DNA. 2020; 11:11. PMC: 7027126. DOI: 10.1186/s13100-020-00206-y. View