Antibacterial and Antioxidant Effects of Magnesium Alloy on Titanium Dental Implants

Overview

Journal Comput Math Methods Med

Publisher Hindawi

Specialty Medical Informatics

Date 2022 Jan 17

PMID 35035523

Authors

Yang Bai

Lin Wang

Lisheng Zhao

E Lingling

Shuo Yang

Shunyi Jia

Ning Wen

Affiliations

Soon will be listed here.

Abstract

Objectives: In this study, a new type of dental implant by covering the surface of the titanium (Ti) implant with zinc-magnesium (Zn-Mg) alloy was designed, to study the antibacterial and antioxidant effects of Mg alloy on titanium (Ti) implants in oral implant restoration.

Methods: Human gingival fibroblasts (HGFs), S. sanguinis, and F. nucleatum bacteria were used to detect the bioactivity and antibacterial properties of Mg alloy-coated Ti implants. In addition, B6/J mice implanted with different materials were used to further detect their antibacterial and antioxidant properties.

Results: The results showed that Mg alloy could better promote the adhesion and proliferation and improve the alkaline phosphatase (ALP) activity of HGFs, which contributed to better improved stability of implant osseointegration. In addition, Mg alloy could better inhibit the proliferation of S. sanguinis, while no significant difference was found in the proliferation of F. nucleatum between the two implants. In the mouse model, the peripheral inflammatory reaction and oxidative stress of the Mg alloy implant were significantly lower than those of the Ti alloy implant.

Conclusions: Zn-Mg alloy-coated Ti implants could better inhibit the growth of Gram-positive bacteria in the oral cavity, inhibit oxidative stress, and facilitate the proliferation activity of HGFs and the potential of osteoblast differentiation, thus, better increasing the stability of implant osseointegration.

Citing Articles

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Retracted: Antibacterial and Antioxidant Effects of Magnesium Alloy on Titanium Dental Implants.

Methods In Medicine C Comput Math Methods Med. 2023; 2023:9760718.

PMID: 38094419 PMC: 10718909. DOI: 10.1155/2023/9760718.

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