GDNF Neurotrophic Factor Signalling Determines the Fate of Dermal Fibroblasts in Wound-induced Hair Neogenesis and Skin Regeneration

Overview

Journal Exp Dermatol

Specialty Dermatology

Date 2022 Jan 12

PMID 35020233

Authors

Neda Vishlaghi

Sandra Rieger

Vanessa McGaughey

Thomas S Lisse

Affiliations

Soon will be listed here.

Abstract

We propose that GDNF, a glial cell line-derived neurotrophic factor, can promote hair follicle neogenesis and skin regeneration after wounding by directing the fate of dermal fibroblasts. Our hypothesis is largely based on detailed GDNF and receptor analysis during skin regenerative stages, as well as the induction of GDNF receptors after wounding between the pro-regenerative spiny mouse (genus Acomys) and its less-regenerative descendant, the house mouse (Mus musculus). To characterize the GDNF-target cells, we will conduct a series of lineage-tracing experiments in conjunction with single-cell RNA and assay for transposase-accessible chromatin sequencing experiments. The heterogenetic dynamics of skin regeneration have yet to be fully defined, and this research will help to advance the fields of regenerative medicine and biology. Finally, we believe that stimulating the GDNF signalling pathway in fibroblasts from less-regenerative animals, such as humans, will promote skin regeneration, morphogenesis and scarless wound healing.

Citing Articles

Reawakening GDNF's regenerative past in mice and humans.

Samos A, McGaughey V, Rieger S, Lisse T Regen Ther. 2022; 20:78-85.

PMID: 35509264 PMC: 9043678. DOI: 10.1016/j.reth.2022.03.008.

GDNF neurotrophic factor signalling determines the fate of dermal fibroblasts in wound-induced hair neogenesis and skin regeneration.

Vishlaghi N, Rieger S, McGaughey V, Lisse T Exp Dermatol. 2022; 31(4):577-581.

PMID: 35020233 PMC: 9306530. DOI: 10.1111/exd.14526.

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