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Gut Microbiome Development in Early Childhood is Affected by Day Care Attendance

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Date 2022 Jan 12
PMID 35017536
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Abstract

The human gut microbiome develops during the first years of life, followed by a relatively stable adult microbiome. Day care attendance is a drastic change that exposes children to a large group of peers in a diverse environment for prolonged periods, at this critical time of microbial development, and therefore has the potential to affect microbial composition. We characterize the effect of day care on the gut microbial development throughout a single school year in 61 children from 4 different day care facilities, and in additional 24 age-matched home care children (n = 268 samples, median age of entering the study was 12 months). We show that day care attendance is a significant and impactful factor in shaping the microbial composition of the growing child, the specific daycare facility and class influence the gut microbiome, and each child becomes more similar to others in their day care. Furthermore, in comparison to home care children, day care children have a different gut microbial composition, with enrichment of taxa more frequently observed in older populations. Our results provide evidence that daycare may be an external factor that contributes to gut microbiome maturation and make-up in early childhood.

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References
1.
Bisgaard H, Hermansen M, Buchvald F, Loland L, Halkjaer L, Bonnelykke K . Childhood asthma after bacterial colonization of the airway in neonates. N Engl J Med. 2007; 357(15):1487-95. DOI: 10.1056/NEJMoa052632. View

2.
Ananthakrishnan A . Epidemiology and risk factors for IBD. Nat Rev Gastroenterol Hepatol. 2015; 12(4):205-17. DOI: 10.1038/nrgastro.2015.34. View

3.
Hermes G, Eckermann H, de Vos W, de Weerth C . Does entry to center-based childcare affect gut microbial colonization in young infants?. Sci Rep. 2020; 10(1):10235. PMC: 7314774. DOI: 10.1038/s41598-020-66404-z. View

4.
Yatsunenko T, Rey F, Manary M, Trehan I, Dominguez-Bello M, Contreras M . Human gut microbiome viewed across age and geography. Nature. 2012; 486(7402):222-7. PMC: 3376388. DOI: 10.1038/nature11053. View

5.
Xu Z, Amir A, Sanders J, Zhu Q, Morton J, Bletz M . Calour: an Interactive, Microbe-Centric Analysis Tool. mSystems. 2019; 4(1). PMC: 6351725. DOI: 10.1128/mSystems.00269-18. View