Synovial Membrane Mesenchymal Stem Cells for Cartilaginous Tissues Repair

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2022 Jan 11

PMID 35013859

Authors

Yessica Zamudio-Cuevas

Ricardo Plata-Rodriguez

Javier Fernandez-Torres

Karina Martinez Flores

Victor Hugo Cardenas-Soria

Anell Olivos-Meza

Adriana Hernandez-Rangel

Carlos Landa-Solis

Affiliations

Soon will be listed here.

Abstract

Background: The present review is focused on general aspects of the synovial membrane as well as specialized aspects of its cellular constituents, particularly the composition and location of synovial membrane mesenchymal stem cells (S-MSCs). S-MSC multipotency properties are currently at the center of translational medicine for the repair of multiple joint tissues, such as articular cartilage and meniscus lesions.

Methods And Results: We reviewed the results of in vitro and in vivo research on the current clinical applications of S-MSCs, surface markers, cell culture techniques, regenerative properties, and immunomodulatory mechanisms of S-MSCs as well as the practical limitations of the last twenty-five years (1996 to 2021).

Conclusions: Despite the poor interest in the development of new clinical trials for the application of S-MSCs in joint tissue repair, we found evidence to support the clinical use of S-MSCs for cartilage repair. S-MSCs can be considered a valuable therapy for the treatment of repairing joint lesions.

Citing Articles

miR-378a-3p Regulates the BMP2-Smad Pathway to Promote Chondrogenic Differentiation of Synovium-Derived Mesenchymal Stem Cells.

Sun X, Long R, Chen Q, Feng J, Gao Y, Zhu G Cell Biochem Biophys. 2024; 83(1):1277-1288.

PMID: 39373905 DOI: 10.1007/s12013-024-01561-w.

The Hippo signalling pathway in bone homeostasis: Under the regulation of mechanics and aging.

Li Z, Lin J, Wu J, Suo J, Wang Z Cell Prolif. 2024; 57(10):e13652.

PMID: 38700015 PMC: 11471399. DOI: 10.1111/cpr.13652.

Osteogenic Potential of Monosodium Urate Crystals in Synovial Mesenchymal Stem Cells.

Martinez-Flores K, Plata-Rodriguez R, Olivos-Meza A, Lopez-Macay A, Fernandez-Torres J, Landa-Solis C Medicina (Kaunas). 2022; 58(12).

PMID: 36556927 PMC: 9786019. DOI: 10.3390/medicina58121724.

References

Wechalekar M, Smith M . Utility of arthroscopic guided synovial biopsy in understanding synovial tissue pathology in health and disease states. World J Orthop. 2014; 5(5):566-73. PMC: 4133463. DOI: 10.5312/wjo.v5.i5.566. View

Orr C, Vieira-Sousa E, Boyle D, Buch M, Buckley C, Canete J . Synovial tissue research: a state-of-the-art review. Nat Rev Rheumatol. 2017; 13(8):463-475. DOI: 10.1038/nrrheum.2017.115. View

Smith M . The normal synovium. Open Rheumatol J. 2012; 5:100-6. PMC: 3263506. DOI: 10.2174/1874312901105010100. View

Jay G, Waller K . The biology of lubricin: near frictionless joint motion. Matrix Biol. 2014; 39:17-24. DOI: 10.1016/j.matbio.2014.08.008. View

Rhee D, Marcelino J, Baker M, Gong Y, Smits P, Lefebvre V . The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth. J Clin Invest. 2005; 115(3):622-31. PMC: 548698. DOI: 10.1172/JCI22263. View

Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D . Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006; 8(4):315-7. DOI: 10.1080/14653240600855905. View

Pittenger M, Mackay A, Beck S, Jaiswal R, Douglas R, Mosca J . Multilineage potential of adult human mesenchymal stem cells. Science. 1999; 284(5411):143-7. DOI: 10.1126/science.284.5411.143. View

Murray I, West C, Hardy W, James A, Park T, Nguyen A . Natural history of mesenchymal stem cells, from vessel walls to culture vessels. Cell Mol Life Sci. 2013; 71(8):1353-74. PMC: 11113613. DOI: 10.1007/s00018-013-1462-6. View

Igura K, Zhang X, Takahashi K, Mitsuru A, Yamaguchi S, Takashi T . Isolation and characterization of mesenchymal progenitor cells from chorionic villi of human placenta. Cytotherapy. 2005; 6(6):543-53. DOI: 10.1080/14653240410005366-1. View

10.

Rogers I, Casper R . Umbilical cord blood stem cells. Best Pract Res Clin Obstet Gynaecol. 2004; 18(6):893-908. DOI: 10.1016/j.bpobgyn.2004.06.004. View

11.

Stanco D, Vigano M, Perucca Orfei C, Di Giancamillo A, Peretti G, Lanfranchi L . Multidifferentiation potential of human mesenchymal stem cells from adipose tissue and hamstring tendons for musculoskeletal cell-based therapy. Regen Med. 2015; 10(6):729-43. DOI: 10.2217/rme.14.92. View

12.

Toma J, Akhavan M, Fernandes K, Sadikot A, Kaplan D, Miller F . Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nat Cell Biol. 2001; 3(9):778-84. DOI: 10.1038/ncb0901-778. View

13.

Tsai M, Lee J, Chang Y, Hwang S . Isolation of human multipotent mesenchymal stem cells from second-trimester amniotic fluid using a novel two-stage culture protocol. Hum Reprod. 2004; 19(6):1450-6. DOI: 10.1093/humrep/deh279. View

14.

Scanzello C, Goldring S . The role of synovitis in osteoarthritis pathogenesis. Bone. 2012; 51(2):249-57. PMC: 3372675. DOI: 10.1016/j.bone.2012.02.012. View

15.

De Bari C, DellAccio F, Tylzanowski P, Luyten F . Multipotent mesenchymal stem cells from adult human synovial membrane. Arthritis Rheum. 2001; 44(8):1928-42. DOI: 10.1002/1529-0131(200108)44:8<1928::AID-ART331>3.0.CO;2-P. View

16.

de Sousa E, Casado P, Moura Neto V, Duarte M, Aguiar D . Synovial fluid and synovial membrane mesenchymal stem cells: latest discoveries and therapeutic perspectives. Stem Cell Res Ther. 2015; 5(5):112. PMC: 4339206. DOI: 10.1186/scrt501. View

17.

Yao Y, Li Z, Zhang H, Zheng Y, Mai L, Liu W . Synovial fluid‑derived synovial fragments represent an improved source of synovial mesenchymal stem cells in the temporomandibular joint. Int J Mol Med. 2017; 41(1):173-183. PMC: 5746324. DOI: 10.3892/ijmm.2017.3210. View

18.

Bilgen B, Ren Y, Pei M, Aaron R, Ciombor D . CD14-negative isolation enhances chondrogenesis in synovial fibroblasts. Tissue Eng Part A. 2009; 15(11):3261-70. PMC: 2792095. DOI: 10.1089/ten.TEA.2008.0273. View

19.

Godoy R, Alves A, Gibson A, Lima E, Goodship A . Do progenitor cells from different tissue have the same phenotype?. Res Vet Sci. 2014; 96(3):454-9. DOI: 10.1016/j.rvsc.2014.02.013. View

20.

Berebichez-Fridman R, Montero-Olvera P . Sources and Clinical Applications of Mesenchymal Stem Cells: State-of-the-art review. Sultan Qaboos Univ Med J. 2019; 18(3):e264-e277. PMC: 6307657. DOI: 10.18295/squmj.2018.18.03.002. View