The Main Anthocyanin Monomer from Murray Fruit Mediates Obesity Via Modulating the Gut Microbiota and Improving the Intestinal Barrier

Overview

Journal Foods

Specialty Biotechnology

Date 2022 Jan 11

PMID 35010223

Authors

Peiyun Liu

Wangting Zhou

Weiqi Xu

Yujia Peng

Yamei Yan

Lu Lu

Jia Mi

Xiaoxiong Zeng

Youlong Cao

Affiliations

Soon will be listed here.

Abstract

Anthocyanins have been shown to exert certain antiobesity properties, but the specific relationship between anthocyanin-induced beneficial effects and the gut microbiota remains unclear. Petunidin-3--[rhamnopyranosyl-(trans--coumaroyl)]-5--(β-D-glucopyranoside) (P3G) is the main anthocyanin monomer from the fruit of Murray. Therefore, in this study, we investigated the antiobesity and remodeling effects of P3G on gut microbiota through a high-fat diet (HFD)-induced obesity mouse model and a fecal microbiota transplantation experiment. P3G was found to reduce body weight gain, fat accumulation, and liver steatosis in HFD-induced obese mice. Moreover, supplementation with P3G alleviated the HFD-induced imbalance in gut microbiota composition, and transferring the P3G-regulated gut microbiota to recipient mice provided comparable protection against obesity. This is the first time evidence is provided that P3G has an antiobesity effect by changing the intestinal microbiota. Our present data highlight a link between P3G intervention and enhancement in gut barrier integrity. This may be a promising option for obesity prevention.

Citing Articles

Effect of potato glycoside alkaloids on mitochondria energy metabolism of , the root rot pathogen of .

Li R, Wang B, Chen W, Zhang C, Li N, Wang Y Front Microbiol. 2025; 15:1512027.

PMID: 39943965 PMC: 11814155. DOI: 10.3389/fmicb.2024.1512027.

Aqueous Extract of Murray Attenuates Neuroinflammation in C57BL/6J Mice Induced by High-Fat and High-Fructose Diet Through Regulating Gut Microbiota and Bile Acid Metabolism.

Fan X, Dong W, Huang Y, Shu Y, Yan Y, Mi J Foods. 2024; 13(23).

PMID: 39682885 PMC: 11640740. DOI: 10.3390/foods13233812.

A review of Murray: Geographic distribution tracing, bioactive components, and functional properties.

Li F, Li H, Li S, He Z Heliyon. 2024; 10(21):e39566.

PMID: 39524793 PMC: 11550641. DOI: 10.1016/j.heliyon.2024.e39566.

The Medicinal Species of the Lycium Genus (Goji Berries) in East Asia: A Review of Its Effect on Cell Signal Transduction Pathways.

Jiang C, Chen Z, Liao W, Zhang R, Chen G, Ma L Plants (Basel). 2024; 13(11).

PMID: 38891336 PMC: 11174690. DOI: 10.3390/plants13111531.

A Lactobacillus Combination Ameliorates Lung Inflammation in an Elastase/LPS-induced Mouse Model of Chronic Obstructive Pulmonary Disease.

Shen H, Fang Y, Tsai W, Chou C, Huang M, Yeh Y Probiotics Antimicrob Proteins. 2024; .

PMID: 38865030 DOI: 10.1007/s12602-024-10300-9.

References

Hirata Y, Ihara S, Koike K . Targeting the complex interactions between microbiota, host epithelial and immune cells in inflammatory bowel disease. Pharmacol Res. 2016; 113(Pt A):574-584. DOI: 10.1016/j.phrs.2016.09.044. View

Schloss P, Westcott S, Ryabin T, Hall J, Hartmann M, Hollister E . Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities. Appl Environ Microbiol. 2009; 75(23):7537-41. PMC: 2786419. DOI: 10.1128/AEM.01541-09. View

Borody T, Paramsothy S, Agrawal G . Fecal microbiota transplantation: indications, methods, evidence, and future directions. Curr Gastroenterol Rep. 2013; 15(8):337. PMC: 3742951. DOI: 10.1007/s11894-013-0337-1. View

Wang J, Tang H, Zhang C, Zhao Y, Derrien M, Rocher E . Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice. ISME J. 2014; 9(1):1-15. PMC: 4274436. DOI: 10.1038/ismej.2014.99. View

Guo J, Han X, Tan H, Huang W, You Y, Zhan J . Blueberry Extract Improves Obesity through Regulation of the Gut Microbiota and Bile Acids via Pathways Involving FXR and TGR5. iScience. 2019; 19:676-690. PMC: 6728616. DOI: 10.1016/j.isci.2019.08.020. View

Thaiss C, Levy M, Grosheva I, Zheng D, Soffer E, Blacher E . Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection. Science. 2018; 359(6382):1376-1383. DOI: 10.1126/science.aar3318. View

Ponziani F, Pecere S, Gasbarrini A, Ojetti V . Physiology and pathophysiology of liver lipid metabolism. Expert Rev Gastroenterol Hepatol. 2015; 9(8):1055-67. DOI: 10.1586/17474124.2015.1056156. View

Fabroni S, Ballistreri G, Amenta M, Romeo F, Rapisarda P . Screening of the anthocyanin profile and in vitro pancreatic lipase inhibition by anthocyanin-containing extracts of fruits, vegetables, legumes and cereals. J Sci Food Agric. 2016; 96(14):4713-4723. DOI: 10.1002/jsfa.7708. View

Ridaura V, Faith J, Rey F, Cheng J, Duncan A, Kau A . Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science. 2013; 341(6150):1241214. PMC: 3829625. DOI: 10.1126/science.1241214. View

10.

Grasset E, Puel A, Charpentier J, Collet X, Christensen J, Terce F . A Specific Gut Microbiota Dysbiosis of Type 2 Diabetic Mice Induces GLP-1 Resistance through an Enteric NO-Dependent and Gut-Brain Axis Mechanism. Cell Metab. 2017; 25(5):1075-1090.e5. DOI: 10.1016/j.cmet.2017.04.013. View

11.

Jia W . Obesity, metabolic syndrome and bariatric surgery: A narrative review. J Diabetes Investig. 2020; 11(2):294-296. PMC: 7078113. DOI: 10.1111/jdi.13236. View

12.

Abdulamir A, Hafidh R, Abu Bakar F . The association of Streptococcus bovis/gallolyticus with colorectal tumors: the nature and the underlying mechanisms of its etiological role. J Exp Clin Cancer Res. 2011; 30:11. PMC: 3032743. DOI: 10.1186/1756-9966-30-11. View

13.

Malik V, Willett W, Hu F . Global obesity: trends, risk factors and policy implications. Nat Rev Endocrinol. 2012; 9(1):13-27. DOI: 10.1038/nrendo.2012.199. View

14.

Zhao L . The gut microbiota and obesity: from correlation to causality. Nat Rev Microbiol. 2013; 11(9):639-47. DOI: 10.1038/nrmicro3089. View

15.

Fabbrini E, Sullivan S, Klein S . Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology. 2009; 51(2):679-89. PMC: 3575093. DOI: 10.1002/hep.23280. View

16.

Su H, Xie L, Xu Y, Ke H, Bao T, Li Y . Pelargonidin-3--glucoside Derived from Wild Raspberry Exerts Antihyperglycemic Effect by Inducing Autophagy and Modulating Gut Microbiota. J Agric Food Chem. 2019; 68(46):13025-13037. DOI: 10.1021/acs.jafc.9b03338. View

17.

Ruocco C, Ragni M, Rossi F, Carullo P, Ghini V, Piscitelli F . Manipulation of Dietary Amino Acids Prevents and Reverses Obesity in Mice Through Multiple Mechanisms That Modulate Energy Homeostasis. Diabetes. 2020; 69(11):2324-2339. PMC: 7576563. DOI: 10.2337/db20-0489. View

18.

Peraldi P, Spiegelman B . TNF-alpha and insulin resistance: summary and future prospects. Mol Cell Biochem. 1998; 182(1-2):169-75. View

19.

Tian B, Zhao J, Xie X, Chen T, Yin Y, Zhai R . Anthocyanins from the fruits of Murray improve high-fat diet-induced insulin resistance by ameliorating inflammation and oxidative stress in mice. Food Funct. 2021; 12(9):3855-3871. DOI: 10.1039/d0fo02936j. View

20.

Chen H, Yang H, Deng J, Fan D . Ginsenoside Rk3 Ameliorates Obesity-Induced Colitis by Regulating of Intestinal Flora and the TLR4/NF-κB Signaling Pathway in C57BL/6 Mice. J Agric Food Chem. 2021; 69(10):3082-3093. DOI: 10.1021/acs.jafc.0c07805. View